Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study

Amy E. Kalkbrenner, Gayle C. Windham, Cheng Zheng, Rob McConnell, Nora L. Lee, James J. Schauer, Brian Thayer, Juhi Pandey, Heather Volk

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Previous studies have reported associations of perinatal exposure to air toxics, including some metals and volatile organic compounds, with autism spectrum disorder (ASD). OBJECTIVES: Our goal was to further explore associations of perinatal air toxics with ASD and associated quantitative traits in high-risk multiplex families. METHODS: We included participants of a U.S. family-based study [the Autism Genetic Resource Exchange (AGRE)] who were born between 1994 and 2007 and had address information. We assessed associations between average annual concentrations at birth for each of 155 air toxics from the U.S. EPA emis-sions-based National-scale Air Toxics Assessment and a) ASD diagnosis (1,540 cases and 477 controls); b) a continuous measure of autism-related traits, the Social Responsiveness Scale (SRS, among 1,272 cases and controls); and c) a measure of autism severity, the Calibrated Severity Score (among 1,380 cases). In addition to the individual’s air toxic level, mixed models (clustering on family) included the family mean air toxic level, birth year, and census covariates, with consideration of the false discovery rate. RESULTS: ASD diagnosis was positively associated with propionaldehyde, methyl tert-butyl ether (MTBE), bromoform, 1,4-dioxane, dibenzofurans, and glycol ethers and was inversely associated with 1,4-dichlorobenzene, 4,40 -methylene diphenyl diisocyanate (MDI), benzidine, and ethyl carbamate (urethane). These associations were robust to adjustment in two-pollutant models. Autism severity was associated positively with carbon disul-fide and chlorobenzene, and negatively with 1,4-dichlorobenzene. There were no associations with the SRS. CONCLUSIONS: Some air toxics were associated with ASD risk and severity, including some traffic-related air pollutants and newly-reported associations, but other previously reported associations with metals and volatile organic compounds were not reproducible.

Original languageEnglish (US)
Article number037004
JournalEnvironmental Health Perspectives
Volume126
Issue number3
DOIs
StatePublished - Mar 1 2018

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Poisons
Autistic Disorder
Air
Phenotype
Volatile Organic Compounds
Urethane
Metals
Parturition
Social Adjustment
Air Pollutants
Glycols
Ethers
Censuses
Cluster Analysis
Carbon
Autism Spectrum Disorder

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Kalkbrenner, A. E., Windham, G. C., Zheng, C., McConnell, R., Lee, N. L., Schauer, J. J., ... Volk, H. (2018). Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study. Environmental Health Perspectives, 126(3), [037004]. https://doi.org/10.1289/EHP1867

Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study. / Kalkbrenner, Amy E.; Windham, Gayle C.; Zheng, Cheng; McConnell, Rob; Lee, Nora L.; Schauer, James J.; Thayer, Brian; Pandey, Juhi; Volk, Heather.

In: Environmental Health Perspectives, Vol. 126, No. 3, 037004, 01.03.2018.

Research output: Contribution to journalArticle

Kalkbrenner, AE, Windham, GC, Zheng, C, McConnell, R, Lee, NL, Schauer, JJ, Thayer, B, Pandey, J & Volk, H 2018, 'Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study', Environmental Health Perspectives, vol. 126, no. 3, 037004. https://doi.org/10.1289/EHP1867
Kalkbrenner AE, Windham GC, Zheng C, McConnell R, Lee NL, Schauer JJ et al. Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study. Environmental Health Perspectives. 2018 Mar 1;126(3). 037004. https://doi.org/10.1289/EHP1867
Kalkbrenner, Amy E. ; Windham, Gayle C. ; Zheng, Cheng ; McConnell, Rob ; Lee, Nora L. ; Schauer, James J. ; Thayer, Brian ; Pandey, Juhi ; Volk, Heather. / Air toxics in relation to autism diagnosis, phenotype, and severity in a U.S. family-based study. In: Environmental Health Perspectives. 2018 ; Vol. 126, No. 3.
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