Air pollution exposure assessment for epidemiologic studies of pregnant women and children

Lessons learned from the Centers for Children's Environmental Health and Disease Prevetion Research

Frank Gilliland, Ed Avol, Patrick Kinney, Michael Jerrett, Timothy Dvonch, Frederick Lurmann, Timothy Buckley, Patrick N Breysse, Gerald Keeler, Tracy de Villiers, Rob McConnell

Research output: Contribution to journalArticle

Abstract

The National Children's Study is considering a wide spectrum of airborne pollutants that are hypothesized to potentially influence pregnancy outcomes, neurodevelopment, asthma, atopy, immune development, obesity, and pubertal development. In this article we summarize six applicable exposure assessment lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research that may enhance the National Children's Study. a) Selecting individual study subjects with a wide range of pollution exposure profiles maximizes spatial-scale exposure contrasts for key pollutants of study interest. b) In studies with large sample sizes, long duration, and diverse outcomes and exposures, exposure assessment efforts should rely on modeling to provide estimates for the entire cohort, supported by subject-derived questionnaire data. c) Assessment of some exposures of interest requires individual measurements of exposures using snapshots of personal and microenvironmental exposures over short periods and/or in selected microenvironments. d) Understanding issues of spatial-temporal correlations of air pollutants, the surrogacy of specific pollutants for components of the complex mixture, and the exposure misclassification inherent in exposure estimates is critical in analysis and interpretation. e) "Usual" temporal, spatial, and physical patterns of activity can be used as modifiers of the exposure/outcome relationships. f) Biomarkers of exposure are useful for evaluation of specific exposures that have multiple routes of exposure. If these lessons are applied, the National Children's Study offers a unique opportunity to assess the adverse effects of air pollution on interrelated health outcomes during the critical early life period.

Original languageEnglish (US)
Pages (from-to)1447-1454
Number of pages8
JournalEnvironmental Health Perspectives
Volume113
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

pollution exposure
health and disease
Environmental Health
Air Pollution
Air pollution
Pregnant Women
Epidemiologic Studies
atmospheric pollution
Health
Air Pollutants
Biomarkers
Complex Mixtures
Research
Pollution
Pregnancy Outcome
Sample Size
Asthma
Obesity
Exercise
Child Health

Keywords

  • Air pollution
  • Airborne
  • Ambient
  • Centers for Children's Environmental Health and Disease Prevention Research
  • Children's Centers
  • Cohort study
  • Direct measurement
  • Exposure assessment
  • Modeling
  • National Children's Study
  • Personal measurement

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Air pollution exposure assessment for epidemiologic studies of pregnant women and children : Lessons learned from the Centers for Children's Environmental Health and Disease Prevetion Research. / Gilliland, Frank; Avol, Ed; Kinney, Patrick; Jerrett, Michael; Dvonch, Timothy; Lurmann, Frederick; Buckley, Timothy; Breysse, Patrick N; Keeler, Gerald; de Villiers, Tracy; McConnell, Rob.

In: Environmental Health Perspectives, Vol. 113, No. 10, 10.2005, p. 1447-1454.

Research output: Contribution to journalArticle

Gilliland, Frank ; Avol, Ed ; Kinney, Patrick ; Jerrett, Michael ; Dvonch, Timothy ; Lurmann, Frederick ; Buckley, Timothy ; Breysse, Patrick N ; Keeler, Gerald ; de Villiers, Tracy ; McConnell, Rob. / Air pollution exposure assessment for epidemiologic studies of pregnant women and children : Lessons learned from the Centers for Children's Environmental Health and Disease Prevetion Research. In: Environmental Health Perspectives. 2005 ; Vol. 113, No. 10. pp. 1447-1454.
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