Abstract
Data regarding the efficacy of cardiac rehabilitation after acute myocardial infarction in advanced age are limited, and are derived from either controlled but non randomized trials, or observational studies. Several aspects of cardiac rehabilitation after myocardial infarction in advanced age, including its effectiveness on exercise tolerance and health- related quality of life, as well as the feasibility of rehabilitation programs, need clarification. The objectives of this randomized, controlled trial, Cardiac Rehabilitation in Advanced Age (CR-AGE), are to examine the effects of an 8-week comprehensive cardiac rehabilitation intervention, comparing 1) supervised outpatient, hospital-based cardiac rehabilitation, 2) home-based cardiac rehabilitation, and 3) usual care in each of three groups of post-myocardial infarction patients, 45-65, 66-75, and 76-85 years of age. The primary objective of the trial is to evaluate the change in physical fitness in each age group assessed by total work capacity at the end of the intervention, and during follow-up over both the medium- (6 months) and the long-term (1 and 2 years). Secondary objectives of the trial include an examination of the feasibility of cardiac rehabilitation in older patients, as well as the determination of the following: exercise complication rates; changes in peak oxygen consumption; changes in other outcome measures, such as health-related quality of life, prevalence of anxiety and depressive symptoms, fluid intelligence, body composition and mass index; incidence of new cardiac and non-cardiac events; and utilization rates of health care services. Enrollment in the CR AGE trial is expected to be completed within the first half of 1998.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 368-376 |
| Number of pages | 9 |
| Journal | Aging clinical and experimental research |
| Volume | 10 |
| Issue number | 5 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Aging
- Cardiac rehabilitation
- Exercise
- Ischemic heart disease
- Myocardial infarction
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
Cite this
Aims, design and enrollment rate of the cardiac rehabilitation in advanced age (CR-AGE) randomized, controlled trial. / Fattirolli, F.; Cartei, A.; Burgisser, C.; Mottino, G.; Del Lungo, F.; Oldridge, N.; Fumagalli, S.; Ferrucci, L.; Masotti, G.; Marchionni, N.
In: Aging clinical and experimental research, Vol. 10, No. 5, 1998, p. 368-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aims, design and enrollment rate of the cardiac rehabilitation in advanced age (CR-AGE) randomized, controlled trial
AU - Fattirolli, F.
AU - Cartei, A.
AU - Burgisser, C.
AU - Mottino, G.
AU - Del Lungo, F.
AU - Oldridge, N.
AU - Fumagalli, S.
AU - Ferrucci, L.
AU - Masotti, G.
AU - Marchionni, N.
PY - 1998
Y1 - 1998
N2 - Data regarding the efficacy of cardiac rehabilitation after acute myocardial infarction in advanced age are limited, and are derived from either controlled but non randomized trials, or observational studies. Several aspects of cardiac rehabilitation after myocardial infarction in advanced age, including its effectiveness on exercise tolerance and health- related quality of life, as well as the feasibility of rehabilitation programs, need clarification. The objectives of this randomized, controlled trial, Cardiac Rehabilitation in Advanced Age (CR-AGE), are to examine the effects of an 8-week comprehensive cardiac rehabilitation intervention, comparing 1) supervised outpatient, hospital-based cardiac rehabilitation, 2) home-based cardiac rehabilitation, and 3) usual care in each of three groups of post-myocardial infarction patients, 45-65, 66-75, and 76-85 years of age. The primary objective of the trial is to evaluate the change in physical fitness in each age group assessed by total work capacity at the end of the intervention, and during follow-up over both the medium- (6 months) and the long-term (1 and 2 years). Secondary objectives of the trial include an examination of the feasibility of cardiac rehabilitation in older patients, as well as the determination of the following: exercise complication rates; changes in peak oxygen consumption; changes in other outcome measures, such as health-related quality of life, prevalence of anxiety and depressive symptoms, fluid intelligence, body composition and mass index; incidence of new cardiac and non-cardiac events; and utilization rates of health care services. Enrollment in the CR AGE trial is expected to be completed within the first half of 1998.
AB - Data regarding the efficacy of cardiac rehabilitation after acute myocardial infarction in advanced age are limited, and are derived from either controlled but non randomized trials, or observational studies. Several aspects of cardiac rehabilitation after myocardial infarction in advanced age, including its effectiveness on exercise tolerance and health- related quality of life, as well as the feasibility of rehabilitation programs, need clarification. The objectives of this randomized, controlled trial, Cardiac Rehabilitation in Advanced Age (CR-AGE), are to examine the effects of an 8-week comprehensive cardiac rehabilitation intervention, comparing 1) supervised outpatient, hospital-based cardiac rehabilitation, 2) home-based cardiac rehabilitation, and 3) usual care in each of three groups of post-myocardial infarction patients, 45-65, 66-75, and 76-85 years of age. The primary objective of the trial is to evaluate the change in physical fitness in each age group assessed by total work capacity at the end of the intervention, and during follow-up over both the medium- (6 months) and the long-term (1 and 2 years). Secondary objectives of the trial include an examination of the feasibility of cardiac rehabilitation in older patients, as well as the determination of the following: exercise complication rates; changes in peak oxygen consumption; changes in other outcome measures, such as health-related quality of life, prevalence of anxiety and depressive symptoms, fluid intelligence, body composition and mass index; incidence of new cardiac and non-cardiac events; and utilization rates of health care services. Enrollment in the CR AGE trial is expected to be completed within the first half of 1998.
KW - Aging
KW - Cardiac rehabilitation
KW - Exercise
KW - Ischemic heart disease
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=0032426918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032426918&partnerID=8YFLogxK
M3 - Article
C2 - 9932140
AN - SCOPUS:0032426918
VL - 10
SP - 368
EP - 376
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 5
ER -