TY - JOUR
T1 - Aiming for the outliers
T2 - Cancer precision medicine through targeting kinases with extreme expression
AU - Yegnasubramanian, Srinivasan
AU - Maitra, Anirban
PY - 2013/3
Y1 - 2013/3
N2 - With the increasing availability of highly potent, pharmacologically active, and selective protein kinase inhibitors, identification of individuals who would benefit from targeted kinase inhibitors could facilitate application of precision medicine strategies for cancer therapy. A recent study by Kothari and colleagues reports preclinical studies that highlight the potential of targeting kinases with extreme expression for cancer precision medicine, warranting further clinical investigation of an individual-specific outlier kinase targeting approach.
AB - With the increasing availability of highly potent, pharmacologically active, and selective protein kinase inhibitors, identification of individuals who would benefit from targeted kinase inhibitors could facilitate application of precision medicine strategies for cancer therapy. A recent study by Kothari and colleagues reports preclinical studies that highlight the potential of targeting kinases with extreme expression for cancer precision medicine, warranting further clinical investigation of an individual-specific outlier kinase targeting approach.
UR - http://www.scopus.com/inward/record.url?scp=84876064910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876064910&partnerID=8YFLogxK
U2 - 10.1158/2159-8290.CD-13-0016
DO - 10.1158/2159-8290.CD-13-0016
M3 - Article
C2 - 23475875
AN - SCOPUS:84876064910
SN - 2159-8274
VL - 3
SP - 252
EP - 254
JO - Cancer discovery
JF - Cancer discovery
IS - 3
ER -