TY - JOUR
T1 - Aiming for 100% Local Control in Locally Advanced Cervical Cancer
T2 - The Role of Complex Brachytherapy Applicators and Intraprocedural Imaging
AU - Elledge, Christen R.
AU - LaVigne, Anna W.
AU - Bhatia, Rohini K.
AU - Viswanathan, Akila N.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/10
Y1 - 2020/10
N2 - The use of brachytherapy for the treatment of gynecologic malignancies, particularly cervical cancer, has a long and rich history that is nearly as long as the history of radiation oncology itself. From the first gynecologic brachytherapy treatments in the early 20th century to the modern era, significant transformation has occurred driven largely by advancements in technology. The development of high-dose rate sources, remote afterloaders, novel applicators, and 3-dimensional image guidance has led to improved local control, and thus improved survival, solidifying the role of brachytherapy as an integral component in the treatment of locally advanced cervical cancer. Current research efforts examining novel magnetic resonance imaging sequences, active magnetic resonance tracking, and the application of hydrogel aim to further improve local control and reduce treatment toxicity.
AB - The use of brachytherapy for the treatment of gynecologic malignancies, particularly cervical cancer, has a long and rich history that is nearly as long as the history of radiation oncology itself. From the first gynecologic brachytherapy treatments in the early 20th century to the modern era, significant transformation has occurred driven largely by advancements in technology. The development of high-dose rate sources, remote afterloaders, novel applicators, and 3-dimensional image guidance has led to improved local control, and thus improved survival, solidifying the role of brachytherapy as an integral component in the treatment of locally advanced cervical cancer. Current research efforts examining novel magnetic resonance imaging sequences, active magnetic resonance tracking, and the application of hydrogel aim to further improve local control and reduce treatment toxicity.
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U2 - 10.1016/j.semradonc.2020.05.002
DO - 10.1016/j.semradonc.2020.05.002
M3 - Review article
C2 - 32828386
AN - SCOPUS:85087310890
SN - 1053-4296
VL - 30
SP - 300
EP - 310
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 4
ER -