TY - JOUR
T1 - AIDS-related primary central nervous system lymphoma
AU - Kasamon, Yvette L.
AU - Ambinder, Richard F.
PY - 2005/8
Y1 - 2005/8
N2 - Because survival of patients infected with HIV has improved with HAART, more patients diagnosed with PCNSL may become candidates for chemotherapy. The role of chemotherapy is far from established, however, and there are clear limitations to dose-intensive approaches in the setting of advanced HIV infection. Because of the rarity of this lymphoma, multicenter collaborations are needed to address these and other fundamental management questions. Further insights into the biology of AIDS PCNSL may translate into new and potentially less immunosuppressive treatments.
AB - Because survival of patients infected with HIV has improved with HAART, more patients diagnosed with PCNSL may become candidates for chemotherapy. The role of chemotherapy is far from established, however, and there are clear limitations to dose-intensive approaches in the setting of advanced HIV infection. Because of the rarity of this lymphoma, multicenter collaborations are needed to address these and other fundamental management questions. Further insights into the biology of AIDS PCNSL may translate into new and potentially less immunosuppressive treatments.
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U2 - 10.1016/j.hoc.2005.05.004
DO - 10.1016/j.hoc.2005.05.004
M3 - Review article
C2 - 16083829
AN - SCOPUS:23244447061
SN - 0889-8588
VL - 19
SP - 665
EP - 687
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 4
ER -