Aids-Related Kaposi's Sarcoma is a Clonal Neoplasm

Charles S. Rabkin, Robert J. Biggar, Gauri Bedi, David Sidransky, Elizabeth Musaba, Rosemary Sunkutu, Nelson Mwansa

Research output: Contribution to journalArticle

Abstract

Kaposi’s sarcoma is generally believed to be a nonneoplastic hyperproliferation because it may regress spontaneously and its spindle cells lack features of typical tumor cells, such as aneuploidy, nuclear atypia, and permissive growth in cell culture. A fundamental characteristic of neoplasms is clonality, in that they arise from clonal replication of a single cell whereas reactive processes are derived from polyclonal proliferation. We used an X chromosome inactivation assay to determine the clonality of Kaposi’s sarcoma nodules from patients with AIDS-related disease. The assay is based on a methyl-sensitive restriction digest followed by PCR amplification of the highly polymorphic androgen receptor gene. Two of three evaluable cases had a monoclonal pattern of inactivation, and the third case had a clonal expansion of cells with an altered microsatellite repeat sequence. These data suggest that Kaposi’s sarcoma (at least in the AIDS setting) is a clonal neoplasm.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalClinical Cancer Research
Volume1
Issue number3
StatePublished - Mar 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Rabkin, C. S., Biggar, R. J., Bedi, G., Sidransky, D., Musaba, E., Sunkutu, R., & Mwansa, N. (1995). Aids-Related Kaposi's Sarcoma is a Clonal Neoplasm. Clinical Cancer Research, 1(3), 257-260.