AIDS-related Kaposi's sarcoma in Brazil: Trends and geopolitical distribution

Valéria Saraceni, Carolina C. Talhari, Gerson F. Pereira, Jonathan E Golub, Sinésio Talhari, Angélica E. Miranda

Research output: Contribution to journalArticle

Abstract

Background: AIDS-related Kaposi's sarcoma (KS) is a unique model of the relationship between viral infection, immunity, environmental, and genetic factors in viral cancers. The goal was to determine the distribution of KS cases among Brazilian geopolitical regions, looking at the ecological relationship with median CD4 cell count. Methods: Ecological study using Brazilian National Diseases Reporting Databases: 1982-2009. Subjects ≥13 years of age who have KS cited in their AIDS reporting form were selected, and demographic and HIV exposure data were collected. Results: We found 11,731 KS cases in the period, with a prevalence of 2.4% among AIDS cases; 88% were male, and 68% lived in the Southeast region, which accounted for 59% of AIDS cases. The regional and national prevalence trends were similar, although the highest proportion among women was found in the North region, which has the lowest number of both AIDS and KS cases. Heterosexual transmission accounted for 87% of HIV among women compared to 18% among men. Fifty-seven percent of all KS cases were diagnosed before antiretroviral therapy (ART). Injection drug use accounted for 11% of KS cases. Median survival was 472 days before the ART era and 1482 after it (P 

Original languageEnglish (US)
Pages (from-to)1525-1529
Number of pages5
JournalInternational Journal of Dermatology
Volume52
Issue number12
DOIs
StatePublished - Dec 2013

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Kaposi's Sarcoma
Brazil
Acquired Immunodeficiency Syndrome
HIV
Heterosexuality
Virus Diseases
CD4 Lymphocyte Count
AIDS-related Kaposi sarcoma
Immunity
Demography
Databases
Injections
Survival
Therapeutics
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Dermatology

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Saraceni, V., Talhari, C. C., Pereira, G. F., Golub, J. E., Talhari, S., & Miranda, A. E. (2013). AIDS-related Kaposi's sarcoma in Brazil: Trends and geopolitical distribution. International Journal of Dermatology, 52(12), 1525-1529. https://doi.org/10.1111/ijd.12116

AIDS-related Kaposi's sarcoma in Brazil : Trends and geopolitical distribution. / Saraceni, Valéria; Talhari, Carolina C.; Pereira, Gerson F.; Golub, Jonathan E; Talhari, Sinésio; Miranda, Angélica E.

In: International Journal of Dermatology, Vol. 52, No. 12, 12.2013, p. 1525-1529.

Research output: Contribution to journalArticle

Saraceni, V, Talhari, CC, Pereira, GF, Golub, JE, Talhari, S & Miranda, AE 2013, 'AIDS-related Kaposi's sarcoma in Brazil: Trends and geopolitical distribution', International Journal of Dermatology, vol. 52, no. 12, pp. 1525-1529. https://doi.org/10.1111/ijd.12116
Saraceni, Valéria ; Talhari, Carolina C. ; Pereira, Gerson F. ; Golub, Jonathan E ; Talhari, Sinésio ; Miranda, Angélica E. / AIDS-related Kaposi's sarcoma in Brazil : Trends and geopolitical distribution. In: International Journal of Dermatology. 2013 ; Vol. 52, No. 12. pp. 1525-1529.
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