AIDS-related Kaposi's sarcoma: A template for the translation of molecular pathogenesis into targeted therapeutic approaches

J. E. Karp, J. M. Pluda, R. Yarchoan

Research output: Contribution to journalArticle

Abstract

AIDS-related Kaposi's sarcoma (KS) represents a complex interaction of host and viral factors. There are a number of fundamental questions surrounding the interplay between the disparate factors that call contribute to the pathogenesis and pathophysiology of this disease. Targets such as the enhancement of immune function, inhibition of angiogenic factors or immunostimulatory cytokines, inhibition of viral proteins such as Tat, or hormonal manipulations are now or will in the future become the focus of research to develop innovative anti-KS therapy and prevention measures. Antiviral approaches aimed at HIV or other viruses may potentially target a number of steps in KS pathogenesis. This article reviews diverse modalities- cytotoxic, antiviral, genedirected, growth factor-targeted, and antiangiogenesis-that singly, or more likely in combination, stand to make an impact on the cure and prevention of AIDS related KS.

Original languageEnglish (US)
Pages (from-to)1031-1049
Number of pages19
JournalHematology/Oncology Clinics of North America
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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