AIDS primary central nervous system lymphoma

Ian W. Flinn, Richard F Ambinder

Research output: Contribution to journalArticle

Abstract

The incidence of primary central nervous system lymphomas is increased several 1000-fold in AIDS patients. These are B-cell malignancies consistently associated with Epstein-Barr virus. They typically occur late in the course of HIV infection and are associated with a very short median survival. The pattern of Epstein-Barr virus gene expression is indicative of severe immunocompromise. Radiographic differentiation from toxoplasmosis remains a problem. Polymerase chain reaction amplification of Epstein-Barr virus DNA in cerebrospinal fluid, 18F-fluoro-deoxyglucose-positron emission tomography scanning, and 201-thallium single-photon emission CT are all promising noninvasive or minimally invasive diagnostic procedures that may obviate the need for brain biopsy in the future. Occasional patients have long remissions after therapy but most patients die within a few months. A possible role for combined modality therapy, including combination chemotherapy, is being explored.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalCurrent Opinion in Oncology
Volume8
Issue number5
StatePublished - 1996

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Human Herpesvirus 4
Lymphoma
Acquired Immunodeficiency Syndrome
Central Nervous System
Combined Modality Therapy
Thallium
Toxoplasmosis
Deoxyglucose
Combination Drug Therapy
Photons
Positron-Emission Tomography
HIV Infections
Cerebrospinal Fluid
B-Lymphocytes
Biopsy
Gene Expression
Polymerase Chain Reaction
Survival
DNA
Incidence

ASJC Scopus subject areas

  • Cancer Research

Cite this

AIDS primary central nervous system lymphoma. / Flinn, Ian W.; Ambinder, Richard F.

In: Current Opinion in Oncology, Vol. 8, No. 5, 1996, p. 373-376.

Research output: Contribution to journalArticle

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