AIDS dementia complex in China

Yun Cheng Wu; Yong Bo Zhao; Meng Guang Tang; Sandy Xinyu Zhang-Nunes; Justin C. McArthur

doi:10.1016/j.jocn.2005.07.012

AIDS dementia complex in China

Yun Cheng Wu, Yong Bo Zhao, Meng Guang Tang, Sandy Xinyu Zhang-Nunes, Justin C. McArthur

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The AIDS dementia complex (ADC) is one of the most common neurological complications in patients with AIDS. However, little is known about the clinical features of ADC in China. We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had short-term memory loss and poor concentration, with preserved alertness. Motor disability was identified in three patients. Of the six ADC patients, two had accompanying vacuolar myelopathy. All of the patients died, with a mean age at death of 41.8 years. The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries.

Original language	English (US)
Pages (from-to)	8-11
Number of pages	4
Journal	Journal of Clinical Neuroscience
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.jocn.2005.07.012
State	Published - Jan 2007

Keywords

AIDS dementia complex
China
HIV
neurological manifestations

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2005.07.012

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title = "AIDS dementia complex in China",

abstract = "The AIDS dementia complex (ADC) is one of the most common neurological complications in patients with AIDS. However, little is known about the clinical features of ADC in China. We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had short-term memory loss and poor concentration, with preserved alertness. Motor disability was identified in three patients. Of the six ADC patients, two had accompanying vacuolar myelopathy. All of the patients died, with a mean age at death of 41.8 years. The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries.",

keywords = "AIDS dementia complex, China, HIV, neurological manifestations",

author = "Wu, {Yun Cheng} and Zhao, {Yong Bo} and Tang, {Meng Guang} and Zhang-Nunes, {Sandy Xinyu} and McArthur, {Justin C.}",

note = "Funding Information: This work was supported in part by a grant from the National Institute of Neurological Diseases and Stroke/National Institutes of Health (NS049465) to Professor Justin C McArthur.",

year = "2007",

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doi = "10.1016/j.jocn.2005.07.012",

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AU - Wu, Yun Cheng

AU - Zhao, Yong Bo

AU - Tang, Meng Guang

AU - Zhang-Nunes, Sandy Xinyu

AU - McArthur, Justin C.

N1 - Funding Information: This work was supported in part by a grant from the National Institute of Neurological Diseases and Stroke/National Institutes of Health (NS049465) to Professor Justin C McArthur.

PY - 2007/1

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N2 - The AIDS dementia complex (ADC) is one of the most common neurological complications in patients with AIDS. However, little is known about the clinical features of ADC in China. We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had short-term memory loss and poor concentration, with preserved alertness. Motor disability was identified in three patients. Of the six ADC patients, two had accompanying vacuolar myelopathy. All of the patients died, with a mean age at death of 41.8 years. The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries.

AB - The AIDS dementia complex (ADC) is one of the most common neurological complications in patients with AIDS. However, little is known about the clinical features of ADC in China. We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had short-term memory loss and poor concentration, with preserved alertness. Motor disability was identified in three patients. Of the six ADC patients, two had accompanying vacuolar myelopathy. All of the patients died, with a mean age at death of 41.8 years. The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries.

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KW - China

KW - HIV

KW - neurological manifestations

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AIDS dementia complex in China

Abstract

Keywords

ASJC Scopus subject areas

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