AIDS and the brain

Research output: Contribution to journalArticle

Abstract

Acquired immune deficiency syndrome (AIDS) continues to increase in incidence worldwide. The AIDS-associated virus selectively infects and destroys T-helper/ inducer (T4) lymphocytes, causing profound deficits in cell-mediated immune responses. Consequently, the nervous system is often affected by opportunistic infections and lymphomas. In addition, the AIDS virus itself appears neurotropic, and may be the direct cause of dementia, myelopathy, and neuropathy; these complications may precede other systemic manifestations of AIDS. This has profound implications on strategies of treatment; comparisons with immune responses of equines and ruminants to related lentiviruses bode ill for vaccine development. On the other hand, the association of a human retrovirus with progressive neurological syndromes in AIDS gives impetus to a search for retroviruses in other chronic inflammatory, degenerative or demyelinating diseases of the nervous system.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalTrends in Neurosciences
Volume9
Issue numberC
DOIs
StatePublished - 1986

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Acquired Immunodeficiency Syndrome
Retroviridae
Nervous System
Brain
HIV
CD4-Positive T-Lymphocytes
Satellite Viruses
Lentivirus
Spinal Cord Diseases
Opportunistic Infections
Ruminants
Demyelinating Diseases
Dementia
Lymphoma
Vaccines
Incidence
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

AIDS and the brain. / Johnson, Richard; McArthur, Justin Charles.

In: Trends in Neurosciences, Vol. 9, No. C, 1986, p. 91-94.

Research output: Contribution to journalArticle

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