AIDS- and non-AIDS-related PML association with distinct p53 polymorphism

C. Power, J. G Brown Gladden, W. Halliday, M. R. Del Bigio, A. Nath, W. Ni, E. O. Major, J. Blanchard, M. Mowat

Research output: Contribution to journalArticle

Abstract

A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non-AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.

Original languageEnglish (US)
Pages (from-to)743-746
Number of pages4
JournalNeurology
Volume54
Issue number3
StatePublished - Feb 8 2000
Externally publishedYes

Fingerprint

Progressive Multifocal Leukoencephalopathy
Acquired Immunodeficiency Syndrome
arginylproline
p53 Genes
Hematologic Neoplasms
Codon
Exons
Population

Keywords

  • AIDS
  • p53 polymorphism
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Power, C., Gladden, J. G. B., Halliday, W., Del Bigio, M. R., Nath, A., Ni, W., ... Mowat, M. (2000). AIDS- and non-AIDS-related PML association with distinct p53 polymorphism. Neurology, 54(3), 743-746.

AIDS- and non-AIDS-related PML association with distinct p53 polymorphism. / Power, C.; Gladden, J. G Brown; Halliday, W.; Del Bigio, M. R.; Nath, A.; Ni, W.; Major, E. O.; Blanchard, J.; Mowat, M.

In: Neurology, Vol. 54, No. 3, 08.02.2000, p. 743-746.

Research output: Contribution to journalArticle

Power, C, Gladden, JGB, Halliday, W, Del Bigio, MR, Nath, A, Ni, W, Major, EO, Blanchard, J & Mowat, M 2000, 'AIDS- and non-AIDS-related PML association with distinct p53 polymorphism', Neurology, vol. 54, no. 3, pp. 743-746.
Power C, Gladden JGB, Halliday W, Del Bigio MR, Nath A, Ni W et al. AIDS- and non-AIDS-related PML association with distinct p53 polymorphism. Neurology. 2000 Feb 8;54(3):743-746.
Power, C. ; Gladden, J. G Brown ; Halliday, W. ; Del Bigio, M. R. ; Nath, A. ; Ni, W. ; Major, E. O. ; Blanchard, J. ; Mowat, M. / AIDS- and non-AIDS-related PML association with distinct p53 polymorphism. In: Neurology. 2000 ; Vol. 54, No. 3. pp. 743-746.
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