AIDS- and non-AIDS-related PML association with distinct p53 polymorphism

C. Power, J. G.Brown Gladden, W. Halliday, M. R. Del Bigio, A. Nath, W. Ni, E. O. Major, J. Blanchard, M. Mowat

Research output: Contribution to journalArticlepeer-review


A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non-AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.

Original languageEnglish (US)
Pages (from-to)743-746
Number of pages4
Issue number3
StatePublished - Feb 8 2000


  • AIDS
  • Progressive multifocal leukoencephalopathy
  • p53 polymorphism

ASJC Scopus subject areas

  • Clinical Neurology


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