Agreement and reproducibility of apparent diffusion coefficient measurements of dual-b-value and multi-b-value diffusion-weighted magnetic resonance imaging at 1.5 tesla in phantom and in soft tissues of the abdomen

Celia Pamela Corona-Villalobos, Li Pan, Vivek Gowdra Halappa, Susanne Bonekamp, Christine H. Lorenz, John Eng, Ihab R. Kamel

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To compare the coefficient of variation (CV) and long-term reproducibility of apparent diffusion coefficient (ADC) in a simple fluid-filled phantom and abdominal organs simultaneously. MATERIALS AND METHODS: Retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study sequentially selected 100 patients who underwent clinically indicated abdominal magnetic resonance imaging. A subset of 58 patients had repeat scans within 2 to 5 months after the initial magnetic resonance imaging. Two diffusion-weighted imaging techniques (b-values 0-750 mm/s) were performed to compare the ADC values. Mean ADC values were calculated for 10 locations and the reference phantom. The CV and Bland-Altman plots were calculated for the phantom and soft tissues at each session and location. RESULTS: There were no significant differences in the mean ADC values between repeated acquisitions. However, ADC values were statistically higher using dual-b-value than multi-b-value diffusion-weighted imaging. The CV for the phantom was 8.6 versus 10.8 for dual-b-value and multi-b-value, respectively. The CVs for the soft tissues had a wider range compared with that of the phantom (liver, 12.6 vs 9.0; spleen, 11.7 vs 11.2; gallbladder, 11.0 vs 13.6; head of pancreas, 14.6 vs 14.7; body of pancreas, 13.4 vs 13.0; tail of pancreas, 14.8 vs 16.3; right kidney, 9.1 vs 9.6; left kidney, 9.3 vs 9.3; right paraspinal muscle, 7.9 vs 7.5; left paraspinal muscle, 7.3 vs 7.3, respectively). CONCLUSIONS: A change in ADC less than 11% falls into the range of measurement variability. Paraspinal muscle could potentially be used as an internal reference parameter.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalJournal of computer assisted tomography
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • abdominal imaging
  • apparent diffusion coefficient
  • diffusion-weighted imaging
  • phantom

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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