Agitation and impulsivity in mid and late life as possible risk markers for incident dementia

for The International Society to Advance Alzheimer's Research and Treatment (ISTAART), Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA)

Research output: Contribution to journalReview articlepeer-review

Abstract

To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre-dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late-onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre-dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre-dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia.

Original languageEnglish (US)
Article numbere12016
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume6
Issue number1
DOIs
StatePublished - 2020

Keywords

  • MBI
  • agitation
  • disinhibition
  • impulse dyscontrol
  • impulsivity
  • mild behavioral impairment
  • pre-dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Agitation and impulsivity in mid and late life as possible risk markers for incident dementia'. Together they form a unique fingerprint.

Cite this