Aging, sex, inflammation, frailty, and CMV and HIV infections

Research output: Contribution to journalReview article

Abstract

Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline and increased vulnerability to infections, but also to play an important role in many chronic conditions such as frailty in older adults. In addition to sex as an important biological factor, chronic viral infections including that by human immunodeficiency virus (HIV) and cytomegalovirus (CMV) are all known to have major impact on the aging immune system. This article provides an overview of our current understanding of aging immunity, sex, inflammation, frailty, and HIV and CMV infections.

Original languageEnglish (US)
Article number104024
JournalCellular Immunology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Virus Diseases
Cytomegalovirus
Immune System
HIV
Inflammation
Cytomegalovirus Infections
Biological Factors
Immunity
Phenotype
Infection
Immunosenescence

Keywords

  • Aging
  • CLIP
  • CMV
  • Frailty
  • HIV
  • Immunosenescence
  • Sex

ASJC Scopus subject areas

  • Immunology

Cite this

Aging, sex, inflammation, frailty, and CMV and HIV infections. / Leng, Sean X.; Margolick, Joseph B.

In: Cellular Immunology, 01.01.2019.

Research output: Contribution to journalReview article

@article{3e801d61802f4893ab9738f6c1f4aad7,
title = "Aging, sex, inflammation, frailty, and CMV and HIV infections",
abstract = "Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline and increased vulnerability to infections, but also to play an important role in many chronic conditions such as frailty in older adults. In addition to sex as an important biological factor, chronic viral infections including that by human immunodeficiency virus (HIV) and cytomegalovirus (CMV) are all known to have major impact on the aging immune system. This article provides an overview of our current understanding of aging immunity, sex, inflammation, frailty, and HIV and CMV infections.",
keywords = "Aging, CLIP, CMV, Frailty, HIV, Immunosenescence, Sex",
author = "Leng, {Sean X.} and Margolick, {Joseph B.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.cellimm.2019.104024",
language = "English (US)",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Aging, sex, inflammation, frailty, and CMV and HIV infections

AU - Leng, Sean X.

AU - Margolick, Joseph B.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline and increased vulnerability to infections, but also to play an important role in many chronic conditions such as frailty in older adults. In addition to sex as an important biological factor, chronic viral infections including that by human immunodeficiency virus (HIV) and cytomegalovirus (CMV) are all known to have major impact on the aging immune system. This article provides an overview of our current understanding of aging immunity, sex, inflammation, frailty, and HIV and CMV infections.

AB - Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline and increased vulnerability to infections, but also to play an important role in many chronic conditions such as frailty in older adults. In addition to sex as an important biological factor, chronic viral infections including that by human immunodeficiency virus (HIV) and cytomegalovirus (CMV) are all known to have major impact on the aging immune system. This article provides an overview of our current understanding of aging immunity, sex, inflammation, frailty, and HIV and CMV infections.

KW - Aging

KW - CLIP

KW - CMV

KW - Frailty

KW - HIV

KW - Immunosenescence

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=85076556275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076556275&partnerID=8YFLogxK

U2 - 10.1016/j.cellimm.2019.104024

DO - 10.1016/j.cellimm.2019.104024

M3 - Review article

C2 - 31843200

AN - SCOPUS:85076556275

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

M1 - 104024

ER -