Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time

Carlos A. Vaz Fragoso, Gail McAvay, Peter H. Van Ness, E. Jeffrey Metter, Luigi Ferrucci, H. Klar Yaggi, John Concato, Thomas M. Gill

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p

Original languageEnglish (US)
Pages (from-to)929-934
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number7
StatePublished - 2016
Externally publishedYes


  • Aging
  • Cardiovascular diseases
  • Epidemiology
  • Lung diseases
  • Spirometry

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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