TY - JOUR
T1 - Aging-related considerations when evaluating the forced expiratory volume in 1 second (FEV1) over time
AU - Vaz Fragoso, Carlos A.
AU - McAvay, Gail
AU - Van Ness, Peter H.
AU - Metter, E. Jeffrey
AU - Ferrucci, Luigi
AU - Yaggi, H. Klar
AU - Concato, John
AU - Gill, Thomas M.
PY - 2016
Y1 - 2016
N2 - Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p
AB - Background: Forced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m3 and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time. Methods: Using linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m3, and Z-scores. Results: Mean baseline values for FEV1 were 3.240 L, 96.4%Pred, 0.621 L/m3, and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040 L, 0.234%Pred, 0.007 L/m3, and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m3 (p
KW - Aging
KW - Cardiovascular diseases
KW - Epidemiology
KW - Lung diseases
KW - Spirometry
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U2 - 10.1093/gerona/glv201
DO - 10.1093/gerona/glv201
M3 - Article
C2 - 26525091
AN - SCOPUS:84979261579
SN - 1079-5006
VL - 71
SP - 929
EP - 934
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 7
ER -