Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice

Serajul I. Khan, Patrick P. Hübner, Alan M. Brichta, Doug W. Smith, Americo A. Migliaccio

Research output: Contribution to journalArticle

Abstract

Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular function, it remains unclear whether aging produces a corresponding decline in VOR function in mice. We sought to determine how the baseline VOR and its short-term adaptation were affected by aging. We tested 8 young (3-month old) and 8 aged (30-month old–equivalent to a ∼80-year old human) C57BL/6 mice. We measured their VOR response to whole-body static tilts and during 0.1–10 Hz whole-body sinusoidal and transient rotations before and after VOR adaptation training. Our data revealed minimal differences in static counter-tilt response between young and aged mice, but a significant deficit in baseline VOR gain in aged mice during transient rotations. Moreover, aged mice had a significant decrease in short-term VOR adaptation, particularly for training that sought to decrease the VOR response.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalNeurobiology of Aging
Volume51
DOIs
StatePublished - Mar 1 2017

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Vestibulo-Ocular Reflex
Ocular Adaptation
Inbred C57BL Mouse

Keywords

  • Aged mice
  • C57BL/6J mice
  • Vestibular adaptation
  • Vestibular plasticity
  • Vestibulo-ocular reflex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice. / Khan, Serajul I.; Hübner, Patrick P.; Brichta, Alan M.; Smith, Doug W.; Migliaccio, Americo A.

In: Neurobiology of Aging, Vol. 51, 01.03.2017, p. 122-131.

Research output: Contribution to journalArticle

Khan, Serajul I. ; Hübner, Patrick P. ; Brichta, Alan M. ; Smith, Doug W. ; Migliaccio, Americo A. / Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice. In: Neurobiology of Aging. 2017 ; Vol. 51. pp. 122-131.
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