TY - JOUR
T1 - Aging, MicroRNAs, and Heart Failure
AU - Florio, Maria Cristina
AU - Magenta, Alessandra
AU - Beji, Sara
AU - Lakatta, Edward G.
AU - Capogrossi, Maurizio C.
N1 - Funding Information:
Source of funding: This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health to M.C.F., E.G.L., and M.C.C. and by the Italian Ministry of Health RF-2016-02362708 to A.M., S.B., and M.C.C.
Publisher Copyright:
© 2019
PY - 2020/12
Y1 - 2020/12
N2 - Aging is a major risk factor for heart failure, one of the leading causes of death in Western society. The mechanisms that underlie the different forms of heart failure have been elucidated only in part and the role of noncoding RNAs is still poorly characterized. Specifically, microRNAs (miRNAs), a class of small noncoding RNAs that can modulate gene expression at the posttranscriptional level in all cells, including myocardial and vascular cells, have been shown to play a role in heart failure with reduced ejection fraction. In contrast, miRNAs role in heart failure with preserved ejection fraction, the predominant form of heart failure in the elderly, is still unknown. In this review, we will focus on age-dependent miRNAs in heart failure and on some other conditions that are prevalent in the elderly and are frequently associated with heart failure with preserved ejection fraction.
AB - Aging is a major risk factor for heart failure, one of the leading causes of death in Western society. The mechanisms that underlie the different forms of heart failure have been elucidated only in part and the role of noncoding RNAs is still poorly characterized. Specifically, microRNAs (miRNAs), a class of small noncoding RNAs that can modulate gene expression at the posttranscriptional level in all cells, including myocardial and vascular cells, have been shown to play a role in heart failure with reduced ejection fraction. In contrast, miRNAs role in heart failure with preserved ejection fraction, the predominant form of heart failure in the elderly, is still unknown. In this review, we will focus on age-dependent miRNAs in heart failure and on some other conditions that are prevalent in the elderly and are frequently associated with heart failure with preserved ejection fraction.
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U2 - 10.1016/j.cpcardiol.2018.12.003
DO - 10.1016/j.cpcardiol.2018.12.003
M3 - Review article
C2 - 30704792
AN - SCOPUS:85060641224
VL - 45
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
SN - 0146-2806
IS - 12
M1 - 100406
ER -