Aging integromics: Module-based markers of heart aging from multi-omics data

Konstantina Dimitrakopoulou, Aristidis G. Vrahatis, Georgios N. Dimitrakopoulos, Anastasios Bezerianos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the emerging Systems Medicine field, the study of aging is re-evaluated and contextualized through the combination of ‘omics’ investigations (i.e. transcriptomic, proteomic, metabolomics, fluxomic). In particular, heart aging is a highly complex process in terms of molecular changes and the role of microRNAs (miRNAs) as key gene regulators has recently arisen. Towards this orientation, we describe a three-step methodological framework for designating markers of heart aging at the level of modules by integrating proteome and heart-specific transcriptome information in the mouse model. First, a Multilayer Large Scale Omics Network (MLSON) is constructed integrating two types of nodes (mRNAs and miRNAs) and three types of relations (mRNA-mRNA, miRNA-mRNA and miRNA-miRNA). Secondly, two adapted weighting schemes were designed and applied on MLSON, based either on mRNA or miRNA expression profiles, with the scope to pinpoint the significantly altered relations due to aging factor. Finally, an efficient module-detecting algorithm, namely Detect Module from Seed Protein (DMSP), is recruited so as to identify multilayer modular markers discriminative of the two states (young/old). Our large scale integromics approach is an enabling step towards elucidating heart longevity mechanisms at multiple levels. The identified modules provide novel biological evidence for the interference and synergistic effect of miRNAs in heart aging process.

Original languageEnglish (US)
Title of host publicationThe 15th International Conference on Biomedical Engineering, ICBME 2013
EditorsJames Goh
PublisherSpringer Verlag
Pages104-107
Number of pages4
ISBN (Electronic)9783319029122
DOIs
StatePublished - Jan 1 2014
Event15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
Duration: Dec 4 2013Dec 7 2013

Publication series

NameIFMBE Proceedings
Volume43
ISSN (Print)1680-0737

Other

Other15th International Conference on Biomedical Engineering, ICBME 2013
Country/TerritorySingapore
CitySingapore
Period12/4/1312/7/13

Keywords

  • Heart aging
  • MRNA
  • MicroRNA
  • Module
  • Network

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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