Aging in Skin of Color

Disruption to Elastic Fiber Organization Is Detrimental to Skin's Biomechanical Function

Abigail Kate Langton, Sabrina Alessi, Mark Hann, Anna Lien-Lun Chien, Sewon Kang, Christopher Ernest Maitland Griffiths, Rachel Elizabeth Beatrice Watson

Research output: Contribution to journalArticle

Abstract

Skin aging is a complex process involving the additive effects of time-dependent intrinsic aging and changes elicited via skin's interaction with the environment. Maintaining optimal skin function is essential for healthy aging across global populations; yet most research focuses on lightly pigmented skin (Fitzpatrick phototypes I–III), with little emphasis on skin of color (Fitzpatrick phototypes V–VI). Here, we explore the biomechanical and histologic consequences of aging in black African-American volunteers. We found that healthy young buttock and dorsal forearm skin was biomechanically resilient, highly elastic, and characterized histologically by strong interdigitation of rete ridges, abundant organized fibrillar collagen, and plentiful arrays of elastic fibers. In contrast, intrinsically aged buttock skin was significantly less resilient, less elastic, and was accompanied by effacement of rete ridges with reduced deposition of both elastic fibers and fibrillar collagens. In chronically photoexposed dorsal forearm, significant impairment of all biomechanical functions was identified, with complete flattening of rete ridges and marked depletion of elastic fibers and fibrillar collagens. We conclude that in skin of color, both intrinsic aging and photoaging significantly impact skin function and composition, despite the additional photoprotective properties of increased melanin. Improved public health advice regarding the consequences of chronic photoexposure and the importance of multimodal photoprotection use for all is of global significance.

Original languageEnglish (US)
JournalJournal of Investigative Dermatology
DOIs
StateAccepted/In press - Jan 1 2019

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Skin Pigmentation
Elastic Tissue
Skin
Aging of materials
Fibrillar Collagens
Color
Fibers
Buttocks
Forearm
Skin Aging
Melanins
African Americans
Volunteers
Public Health
Public health
Research
Population

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Aging in Skin of Color : Disruption to Elastic Fiber Organization Is Detrimental to Skin's Biomechanical Function. / Langton, Abigail Kate; Alessi, Sabrina; Hann, Mark; Chien, Anna Lien-Lun; Kang, Sewon; Griffiths, Christopher Ernest Maitland; Watson, Rachel Elizabeth Beatrice.

In: Journal of Investigative Dermatology, 01.01.2019.

Research output: Contribution to journalArticle

Langton, Abigail Kate ; Alessi, Sabrina ; Hann, Mark ; Chien, Anna Lien-Lun ; Kang, Sewon ; Griffiths, Christopher Ernest Maitland ; Watson, Rachel Elizabeth Beatrice. / Aging in Skin of Color : Disruption to Elastic Fiber Organization Is Detrimental to Skin's Biomechanical Function. In: Journal of Investigative Dermatology. 2019.
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