Aging effects on memory encoding in the frontal lobes

Glenn T. Stebbins; Maria C. Carrillo; Jennifer Dorfman; Courtney Dirksen; John E. Desmond; David A. Turner; David A. Bennett; Robert S. Wilson; Gary Glover; John D.E. Gabrieli

doi:10.1037/0882-7974.17.1.44

Aging effects on memory encoding in the frontal lobes

Glenn T. Stebbins, Maria C. Carrillo, Jennifer Dorfman, Courtney Dirksen, John E. Desmond, David A. Turner, David A. Bennett, Robert S. Wilson, Gary Glover, John D.E. Gabrieli

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) was used to compare frontal-lobe activation in younger and older adults during encoding of words into memory. Participants made semantic or nonsemantic judgments about words. Younger adults exhibited greater activation for semantic relative to nonsemantic judgments in several regions, with the largest activation in the left inferior frontal gyrus. Older adults exhibited greater activation for semantic judgments in the same regions, but the extent of activation was reduced in left prefrontal regions. In older adults, there was a significant association between behavioral tests of declarative and working memory and extent of frontal activation. These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience.

Original language	English (US)
Pages (from-to)	44-55
Number of pages	12
Journal	Psychology and aging
Volume	17
Issue number	1
DOIs	https://doi.org/10.1037/0882-7974.17.1.44
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Social Psychology
Aging
Geriatrics and Gerontology

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title = "Aging effects on memory encoding in the frontal lobes",

abstract = "Functional magnetic resonance imaging (fMRI) was used to compare frontal-lobe activation in younger and older adults during encoding of words into memory. Participants made semantic or nonsemantic judgments about words. Younger adults exhibited greater activation for semantic relative to nonsemantic judgments in several regions, with the largest activation in the left inferior frontal gyrus. Older adults exhibited greater activation for semantic judgments in the same regions, but the extent of activation was reduced in left prefrontal regions. In older adults, there was a significant association between behavioral tests of declarative and working memory and extent of frontal activation. These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience.",

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T1 - Aging effects on memory encoding in the frontal lobes

AU - Stebbins, Glenn T.

AU - Carrillo, Maria C.

AU - Dorfman, Jennifer

AU - Dirksen, Courtney

AU - Desmond, John E.

AU - Turner, David A.

AU - Bennett, David A.

AU - Wilson, Robert S.

AU - Glover, Gary

AU - Gabrieli, John D.E.

PY - 2002

Y1 - 2002

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AB - Functional magnetic resonance imaging (fMRI) was used to compare frontal-lobe activation in younger and older adults during encoding of words into memory. Participants made semantic or nonsemantic judgments about words. Younger adults exhibited greater activation for semantic relative to nonsemantic judgments in several regions, with the largest activation in the left inferior frontal gyrus. Older adults exhibited greater activation for semantic judgments in the same regions, but the extent of activation was reduced in left prefrontal regions. In older adults, there was a significant association between behavioral tests of declarative and working memory and extent of frontal activation. These results suggest that age-associated decreases in memory ability may be due to decreased frontal-lobe contributions to the initial encoding of experience.

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Aging effects on memory encoding in the frontal lobes

Abstract

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