Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

James B. Strait; Edward G. Lakatta

doi:10.1016/j.hfc.2011.08.011

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

James B. Strait, Edward G. Lakatta

Research output: Contribution to journal › Review article › peer-review

298 Scopus citations

Abstract

Aging represents a convergence of declining cardioprotective systems and increasing disease processes that is fertile ground for the development of heart failure. Fifty percent of all heart failure diagnoses and 90% of all heart failure deaths occur in individuals older than 70. This article discusses the microscopic and macroscopic changes in cardiovascular structure, function, protective systems, and disease associated with aging. In addition to outlining important clinical considerations and conditions in older persons, the link between normal aging and the elevated risk for development of stage B heart failure is explained and potential therapeutic pathways are highlighted.

Original language	English (US)
Pages (from-to)	143-164
Number of pages	22
Journal	Heart Failure Clinics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.hfc.2011.08.011
State	Published - Jan 2012
Externally published	Yes

Keywords

Cardiac function
Cardiac reserve
Cardiovascular aging
Heart failure

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2011.08.011

Cite this

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abstract = "Aging represents a convergence of declining cardioprotective systems and increasing disease processes that is fertile ground for the development of heart failure. Fifty percent of all heart failure diagnoses and 90% of all heart failure deaths occur in individuals older than 70. This article discusses the microscopic and macroscopic changes in cardiovascular structure, function, protective systems, and disease associated with aging. In addition to outlining important clinical considerations and conditions in older persons, the link between normal aging and the elevated risk for development of stage B heart failure is explained and potential therapeutic pathways are highlighted.",

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AB - Aging represents a convergence of declining cardioprotective systems and increasing disease processes that is fertile ground for the development of heart failure. Fifty percent of all heart failure diagnoses and 90% of all heart failure deaths occur in individuals older than 70. This article discusses the microscopic and macroscopic changes in cardiovascular structure, function, protective systems, and disease associated with aging. In addition to outlining important clinical considerations and conditions in older persons, the link between normal aging and the elevated risk for development of stage B heart failure is explained and potential therapeutic pathways are highlighted.

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KW - Cardiac reserve

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KW - Heart failure

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Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

Abstract

Keywords

ASJC Scopus subject areas

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