Abstract
Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging-associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7-DC + (PD-L2/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7-DC + B cells from aged mice, and this effect was blocked with anti-B7-DC antibodies in vitro and in vivo. Moreover, retardation of tumor growth in aged mice was largely B7-DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7-DC + B cells from aged mice owing to increased induction of tumor antigen-specific cytotoxic T lymphocytes. These data indicate that B7-DC + B cells could play an important role in aging-associated cancer immunopathology as well as in other aging-associated diseases and further suggest that B7-DC + B cells have potential for future cancer immunotherapy.
Original language | English (US) |
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Pages (from-to) | 128-138 |
Number of pages | 11 |
Journal | Aging Cell |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2012 |
Keywords
- Antitumor immunity
- B cell
- B7-DC
- Co-stimulation
- Cytotoxic T lymphocyte
- PD-L2
- Th17
ASJC Scopus subject areas
- Aging
- Cell Biology