Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

Elisa Fabbri, Marco Zoli, Marta Gonzalez-Freire, Marcel E. Salive, Stephanie A. Studenski, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities.

Original languageEnglish (US)
Pages (from-to)640-647
Number of pages8
JournalJournal of the American Medical Directors Association
Volume16
Issue number8
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Keywords

  • Aging
  • Chronic disease
  • Multimorbidity
  • Multiple morbidities

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)
  • Health Policy

Fingerprint Dive into the research topics of 'Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research'. Together they form a unique fingerprint.

  • Cite this