Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis

Anne Hammer, Anne Rositch, Fares Qeadan, Patti E. Gravitt, Jan Blaakaer

Research output: Contribution to journalReview article

Abstract

The prevalence of HPV16/18 in cervical cancer has been reported to decline with age in some papers. However, whether this decline in proportion of cancers positive for HPV16/18 is consistently observed across studies remains to be elucidated. Thus, the aim of this study was to identify papers reporting data on age-specific prevalence of HPV16/18 in cervical cancer and to summarize the results. We employed MEDLINE and Embase for a systematic literature search and thereby identified a total of 644 papers published in the period 1999-2015, of which 15 papers, reporting cross-sectional data, were included for review (11,526 cervical cancers). The prevalence of HPV16/18 in cervical cancer declined significantly with age (ρ = -0.83, p = 0.04) from 74.8% (95% CI 67.6-80.8) in women aged 30-39 years to 56.8% (95% CI 43.9-68.8) in women aged ≥70 years. As the HPV16/18 positive cancers are prevented in fully vaccinated cohorts, the age-specific epidemiology of cervical cancer is anticipated to change, with a shift in peak incidence rate to older ages. It will be important for integrated vaccination and screening strategies to consider predicted change in the age-specific epidemiology of cervical cancer.

Original languageEnglish (US)
Pages (from-to)2795-2803
Number of pages9
JournalInternational Journal of Cancer
Volume138
Issue number12
DOIs
StatePublished - Jun 15 2016

Keywords

  • HPV vaccine
  • cervical cancer
  • cervical cancer screening
  • human papilloma virus
  • review

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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