TY - GEN
T1 - Age-related subpathway detection through meta-analysis of multiple gene expression datasets
AU - Dimitrakopoulos, Georgios N.
AU - Vrahatis, Aristidis G.
AU - Balomenos, Panos
AU - Sgarbas, Kyriakos
AU - Bezerianos, Anastasios
PY - 2015/9/9
Y1 - 2015/9/9
N2 - A novel perspective of systems biology is the incorporation of pathway structure data along with transcriptomics studies. In parallel, the plethora of high-throughput experimental studies necessitates employment of meta-analysis approaches in order to obtain more biologically consistent results. Towards this orientation we developed a subpathway-based meta-analysis method that integrates human pathway maps along with multiple human mRNA expression experiments. Our method succeeded to identify known age-related subpathways as differentially expressed exploiting several independent muscle-specific aging studies. Finally, our method is applicable in several complex biological problems where massive amount of time series expression data is available.
AB - A novel perspective of systems biology is the incorporation of pathway structure data along with transcriptomics studies. In parallel, the plethora of high-throughput experimental studies necessitates employment of meta-analysis approaches in order to obtain more biologically consistent results. Towards this orientation we developed a subpathway-based meta-analysis method that integrates human pathway maps along with multiple human mRNA expression experiments. Our method succeeded to identify known age-related subpathways as differentially expressed exploiting several independent muscle-specific aging studies. Finally, our method is applicable in several complex biological problems where massive amount of time series expression data is available.
KW - aging
KW - meta-analysis
KW - microarrays
KW - pathways
KW - subpathways
UR - http://www.scopus.com/inward/record.url?scp=84961333345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961333345&partnerID=8YFLogxK
U2 - 10.1109/ICDSP.2015.7251931
DO - 10.1109/ICDSP.2015.7251931
M3 - Conference contribution
AN - SCOPUS:84961333345
T3 - International Conference on Digital Signal Processing, DSP
SP - 539
EP - 542
BT - 2015 IEEE International Conference on Digital Signal Processing, DSP 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE International Conference on Digital Signal Processing, DSP 2015
Y2 - 21 July 2015 through 24 July 2015
ER -