TY - JOUR
T1 - Age-related prevalence of Shigella and Salmonella antibodies and their association with diarrhoeal diseases in Peruvian children
AU - Minh, Nguyen B.
AU - Lanata, Claudio F.
AU - Black, Robert E.
AU - Gil, Ana I.
AU - Kärnell, Anders
AU - Wretlind, Bengt
N1 - Funding Information:
Written informed consent was obtained from the parents of participating children. The study was approved by the Peruvian Ministry of Health, the Peruvian College of Physicians, the ethics committees of the Instituto de Investigación Nutricional Peru, the Clinical Research Subpanel of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) USA, the Johns Hopkins School of Hygiene and Public Health USA, and the Pan-American and World Health Organizations and by community leaders of the study area.
PY - 1998
Y1 - 1998
N2 - Shigella and Salmonella antibodies in relation to diarrhoea were studied in a cohort of 413 children between 2 and 27 months of age in peri-urban Lima, Peru. Blood samples were obtained at 2, 3 and 12 months of age. Antibody titres against lipopolysaccharide from Shigella flexneri serotype Y, Shigella dysenteriae serotype 1, Shigella sonnei, Salmonella serogroups AO, BO, DO, and Shigella Ipa and Salmonella typhi Vi antigens were measured by enzyme immunoassay. IgG titres against S. flexneri and Shigella Ipa were higher at 2 than at 3 or 12 months of age (p = 0.001), while the changes in IgG titres against S. dysenteriae, S. sonnei and Salmonella were not pronounced. IgA and IgM titres against S. flexneri, Shigella Ipa, S. dysenteriae, S. sonnei and Salmonella were significantly higher at 12 than at 2 or 3 months of age (p = 0.001). Stool samples were obtained from children in 64% of all diarrhoeal episodes, Shigella spp. were isolated from 20% of the children during the first 2 y of lift and Salmonella in 3%. Most isolates were from children at 13-24 months of age (78%). IgG antibodies at 12 months of age did not protect against shigellosis during the second year of life.
AB - Shigella and Salmonella antibodies in relation to diarrhoea were studied in a cohort of 413 children between 2 and 27 months of age in peri-urban Lima, Peru. Blood samples were obtained at 2, 3 and 12 months of age. Antibody titres against lipopolysaccharide from Shigella flexneri serotype Y, Shigella dysenteriae serotype 1, Shigella sonnei, Salmonella serogroups AO, BO, DO, and Shigella Ipa and Salmonella typhi Vi antigens were measured by enzyme immunoassay. IgG titres against S. flexneri and Shigella Ipa were higher at 2 than at 3 or 12 months of age (p = 0.001), while the changes in IgG titres against S. dysenteriae, S. sonnei and Salmonella were not pronounced. IgA and IgM titres against S. flexneri, Shigella Ipa, S. dysenteriae, S. sonnei and Salmonella were significantly higher at 12 than at 2 or 3 months of age (p = 0.001). Stool samples were obtained from children in 64% of all diarrhoeal episodes, Shigella spp. were isolated from 20% of the children during the first 2 y of lift and Salmonella in 3%. Most isolates were from children at 13-24 months of age (78%). IgG antibodies at 12 months of age did not protect against shigellosis during the second year of life.
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U2 - 10.1080/003655498750003555
DO - 10.1080/003655498750003555
M3 - Article
C2 - 9730303
AN - SCOPUS:0031842548
VL - 30
SP - 159
EP - 164
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 2
ER -