Age-related hemodynamic effects of intravenous nitroglycerin for acute myocardial infarction and left ventricular failure

Niccolo' Marchionni, Adam Schneeweiss, Mauro Di Bari, Luigi Ferrucci, Guya Moschi, Bernardo Salani, Marco Paoletti, Costanza Burgisser, Stefano Fumagalli

Research output: Contribution to journalArticlepeer-review

Abstract

Acute hemodynamic effects of intravenous nitroglycerin (NTG) were assessed in 24 patients with acute myocardial infarction and left ventricular failure, and results were compared between 2 groups of different age (group A-65 years or less, n = 12; group B-75 years or more, n = 12). Overall, hemodynamic effects of NTG consisted of an increase in stroke volume index and left ventricular stroke work index (+21 and +23%), coupled with a 16% reduction in systemic vascular resistance, and of a marked decrease in right atrial and pulmonary artery (PA) pressures. The hemodynamic endpoint (5 to 10% reduction in mean systemic arterial pressure) used for NTG titration was achieved with a significantly lower dose in group B, in which a greater percent reduction in mean PA and mean PA wedge pressures was also observed. However, because effects of NTG on systemic vascular resistance were similar in groups A and B, it was concluded that the vasodilating action of NTG is maintained in advanced age, as opposed to what has been demonstrated for β-adrenergic agents.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalThe American Journal of Cardiology
Volume61
Issue number9
DOIs
StatePublished - Mar 25 1988
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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