Age-related changes of myocardial ATP supply and demand mechanisms

Yael Yaniv, Magdalena Juhaszova, Steven J. Sollott

Research output: Contribution to journalArticle

Abstract

In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels.

Original languageEnglish (US)
Pages (from-to)495-505
Number of pages11
JournalTrends in Endocrinology and Metabolism
Volume24
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Aging
  • Bioenergetics
  • Cardiac work
  • Mitochondria
  • Respiration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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