Abstract
In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels.
Original language | English (US) |
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Pages (from-to) | 495-505 |
Number of pages | 11 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 24 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2013 |
Externally published | Yes |
Keywords
- Aging
- Bioenergetics
- Cardiac work
- Mitochondria
- Respiration
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism