Age-related changes of myocardial ATP supply and demand mechanisms

Yael Yaniv; Magdalena Juhaszova; Steven J. Sollott

doi:10.1016/j.tem.2013.06.001

Age-related changes of myocardial ATP supply and demand mechanisms

Yael Yaniv, Magdalena Juhaszova, Steven J. Sollott

Research output: Contribution to journal › Article

Abstract

In advanced age, the resting myocardial oxygen consumption rate (MVO₂) and cardiac work (CW) in the rat remain intact. However, MVO₂, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mechanisms, and critique experimental models used to investigate aging. Specifically, we evaluate experimental data collected at the level of isolated mitochondria, tissue, or organism, and discuss how mitochondrial energetic mechanisms change in advanced age, both at basal and high energy-demand levels.

Original language	English (US)
Pages (from-to)	495-505
Number of pages	11
Journal	Trends in Endocrinology and Metabolism
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2013.06.001
State	Published - Oct 2013
Externally published	Yes

Keywords

Aging
Bioenergetics
Cardiac work
Mitochondria
Respiration

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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Yaniv, Y., Juhaszova, M., & Sollott, S. J. (2013). Age-related changes of myocardial ATP supply and demand mechanisms. Trends in Endocrinology and Metabolism, 24(10), 495-505. https://doi.org/10.1016/j.tem.2013.06.001

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