Age-related changes in the nigrostriatum

A behavioral and biochemical analysis

J. A. Joseph, R. E. Berger, B. T. Engel, G. S. Roth

Research output: Contribution to journalArticle

Abstract

Rotational behavior was examined prior to (Exp. 1) and following unilateral lesions (Exp. 2) in the substantia nigra of young and old rats. Before lesioning no preferences for turning to the left or right were seen in either age group following graded doses of amphetamine. However, after radiofrequency lesions of the left substantia nigra both young and old rats turned predominantly to the left, and the ratio of left to right turns increased as a function of amphetamine dose. However, there were significant differences between young and old rats in the effect of amphetamine on rotational behavior, with old rats showing decided decrements in response strength. Direct dopaminergic stimulation under apomorphine or dopaminergic receptor blockade with halperidol produced no such age related deficits. The results are discussed in terms of possible presynaptic alterations in dopaminergic functioning with aging.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalJournals of Gerontology
Volume33
Issue number5
StatePublished - 1978

Fingerprint

Amphetamine
Substantia Nigra
Apomorphine
Age Groups

ASJC Scopus subject areas

  • Aging

Cite this

Joseph, J. A., Berger, R. E., Engel, B. T., & Roth, G. S. (1978). Age-related changes in the nigrostriatum: A behavioral and biochemical analysis. Journals of Gerontology, 33(5), 643-649.

Age-related changes in the nigrostriatum : A behavioral and biochemical analysis. / Joseph, J. A.; Berger, R. E.; Engel, B. T.; Roth, G. S.

In: Journals of Gerontology, Vol. 33, No. 5, 1978, p. 643-649.

Research output: Contribution to journalArticle

Joseph, JA, Berger, RE, Engel, BT & Roth, GS 1978, 'Age-related changes in the nigrostriatum: A behavioral and biochemical analysis', Journals of Gerontology, vol. 33, no. 5, pp. 643-649.
Joseph, J. A. ; Berger, R. E. ; Engel, B. T. ; Roth, G. S. / Age-related changes in the nigrostriatum : A behavioral and biochemical analysis. In: Journals of Gerontology. 1978 ; Vol. 33, No. 5. pp. 643-649.
@article{b720f1f4ed9e4ac19c0b01fcdd032b95,
title = "Age-related changes in the nigrostriatum: A behavioral and biochemical analysis",
abstract = "Rotational behavior was examined prior to (Exp. 1) and following unilateral lesions (Exp. 2) in the substantia nigra of young and old rats. Before lesioning no preferences for turning to the left or right were seen in either age group following graded doses of amphetamine. However, after radiofrequency lesions of the left substantia nigra both young and old rats turned predominantly to the left, and the ratio of left to right turns increased as a function of amphetamine dose. However, there were significant differences between young and old rats in the effect of amphetamine on rotational behavior, with old rats showing decided decrements in response strength. Direct dopaminergic stimulation under apomorphine or dopaminergic receptor blockade with halperidol produced no such age related deficits. The results are discussed in terms of possible presynaptic alterations in dopaminergic functioning with aging.",
author = "Joseph, {J. A.} and Berger, {R. E.} and Engel, {B. T.} and Roth, {G. S.}",
year = "1978",
language = "English (US)",
volume = "33",
pages = "643--649",
journal = "Journal of Gerontology: Social Sciences",
issn = "0022-1422",
publisher = "Gerontological Society of America",
number = "5",

}

TY - JOUR

T1 - Age-related changes in the nigrostriatum

T2 - A behavioral and biochemical analysis

AU - Joseph, J. A.

AU - Berger, R. E.

AU - Engel, B. T.

AU - Roth, G. S.

PY - 1978

Y1 - 1978

N2 - Rotational behavior was examined prior to (Exp. 1) and following unilateral lesions (Exp. 2) in the substantia nigra of young and old rats. Before lesioning no preferences for turning to the left or right were seen in either age group following graded doses of amphetamine. However, after radiofrequency lesions of the left substantia nigra both young and old rats turned predominantly to the left, and the ratio of left to right turns increased as a function of amphetamine dose. However, there were significant differences between young and old rats in the effect of amphetamine on rotational behavior, with old rats showing decided decrements in response strength. Direct dopaminergic stimulation under apomorphine or dopaminergic receptor blockade with halperidol produced no such age related deficits. The results are discussed in terms of possible presynaptic alterations in dopaminergic functioning with aging.

AB - Rotational behavior was examined prior to (Exp. 1) and following unilateral lesions (Exp. 2) in the substantia nigra of young and old rats. Before lesioning no preferences for turning to the left or right were seen in either age group following graded doses of amphetamine. However, after radiofrequency lesions of the left substantia nigra both young and old rats turned predominantly to the left, and the ratio of left to right turns increased as a function of amphetamine dose. However, there were significant differences between young and old rats in the effect of amphetamine on rotational behavior, with old rats showing decided decrements in response strength. Direct dopaminergic stimulation under apomorphine or dopaminergic receptor blockade with halperidol produced no such age related deficits. The results are discussed in terms of possible presynaptic alterations in dopaminergic functioning with aging.

UR - http://www.scopus.com/inward/record.url?scp=0018073624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018073624&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 643

EP - 649

JO - Journal of Gerontology: Social Sciences

JF - Journal of Gerontology: Social Sciences

SN - 0022-1422

IS - 5

ER -