Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice

Hristelina S. Ilieva, Isao Nagano, Tetsuro Murakami, Mito Shiote, Yasuhiro Manabe, Koji Abe

Research output: Contribution to journalArticle

Abstract

Peroxisomal membrane protein 70 (PMP70) and Cu/Zn superoxide dismutase (SOD1) were examined in the spinal cords of transgenic (Tg) mice expressing a human mutant SOD1 protein (G93A) and their age-matched controls at 8, 20 and 32 weeks by immunohistochemistry. At pre-symptomatic 20 weeks and symptomatic 32 weeks, PMP70 was reduced in the cytoplasm of motor neurons in Tg animals and increased in glial cells in anterior horn at late age. SOD1 showed a progressive increase of dot-like deposits in the neuropil of anterior horn of Tg mice, and a late decrease of signal intensity in the white matter and motor neurons at 32 weeks. It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalNeurological research
Volume25
Issue number4
DOIs
StatePublished - Jun 2003

Keywords

  • Amyotrophic lateral sclerosis
  • Cu/Zn superoxide dismutase
  • Peroxisome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice'. Together they form a unique fingerprint.

  • Cite this