@inproceedings{f97828af8f0b49fb923ba1429d513685,
title = "Age-related changes in nociceptive processing in the human brain",
abstract = "Functional magnetic resonance imaging (fMRI) was used to compare cortical nociceptive responses to painful contact heat in healthy young (ages 22-30, n = 7) and older (ages 56-75, n = 7) subjects. Compared to young subjects, older subjects had significantly smaller painrelated fMRI responses in anterior insula (aINS) (P < 0.04), primary somatosensory cortex (S1) (P = 0.03), and supplementary motor area (P = 0.02). Gray matter volumes in S1 and aINS were significantly smaller for the older group (P = 0.02 and 0.0001, respectively), suggesting reduced processing capacity in these regions that might account for smaller pain-related fMRI responses.",
keywords = "Aging, Cortex, Nociception, Pain, fMRI",
author = "Quiton, {Raimi L.} and Roys, {Steven R.} and Jiachen Zhuo and Keaser, {Michael L.} and Gullapalli, {Rao P.} and Greenspan, {Joel D.}",
year = "2007",
month = feb,
doi = "10.1196/annals.1379.024",
language = "English (US)",
isbn = "1573316598",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "175--178",
booktitle = "Imaging and the Aging Brain",
}