Age-related changes in nociceptive processing in the human brain

Raimi L. Quiton, Steven R. Roys, Jiachen Zhuo, Michael L. Keaser, Rao P. Gullapalli, Joel D. Greenspan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Functional magnetic resonance imaging (fMRI) was used to compare cortical nociceptive responses to painful contact heat in healthy young (ages 22-30, n = 7) and older (ages 56-75, n = 7) subjects. Compared to young subjects, older subjects had significantly smaller painrelated fMRI responses in anterior insula (aINS) (P < 0.04), primary somatosensory cortex (S1) (P = 0.03), and supplementary motor area (P = 0.02). Gray matter volumes in S1 and aINS were significantly smaller for the older group (P = 0.02 and 0.0001, respectively), suggesting reduced processing capacity in these regions that might account for smaller pain-related fMRI responses.

Original languageEnglish (US)
Title of host publicationImaging and the Aging Brain
PublisherBlackwell Publishing Inc.
Number of pages4
ISBN (Print)1573316598, 9781573316590
StatePublished - Feb 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Aging
  • Cortex
  • Nociception
  • Pain
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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