Age-related changes in multiple neurotransmitter systems in the monkey brain

Gary L. Wenk, Donna J. Pierce, Robert G. Struble, Donald L. Price, Linda C. Cork

Research output: Contribution to journalArticle

Abstract

Age-associated changes in cholinergic, monoaminergic and amino acid neurotransmitter systems were analyzed in 14 brain regions of 23 rhesus monkeys that ranged in age from 2 to 37 years. In the frontal pole, the levels of choline acetyltransferase (ChAT) activity, the density of [3H]ketanserin (serotonin type-2) binding sites and endogenous levels of dopamine, homovanillic acid and serotonin, all expressed per milligram of protein, decreased significantly with aging. In precentral motor cortex, ChAT activity decreased; in parietal and occipital cortex, the number of [3H]ketanserin binding sites decreased while the number of Na+-independent [3H]glutamate binding sites increased with age. In the caudate nucleus, endogenous levels of norepinephrine decreased. This descriptive study indicates that the aging monkey may be a very useful model for future investigations of age-associated transmitter abnormalities similar to those that occur in humans.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalNeurobiology of Aging
Volume10
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Haplorhini
Neurotransmitter Agents
Ketanserin
Choline O-Acetyltransferase
Binding Sites
Serotonin
Brain
Occipital Lobe
Homovanillic Acid
Parietal Lobe
Caudate Nucleus
Motor Cortex
Macaca mulatta
Cholinergic Agents
Glutamic Acid
Dopamine
Norepinephrine
Amino Acids
Proteins

Keywords

  • Acetylcholine
  • Aging
  • Cortex
  • Glutamate
  • Monkeys
  • Monoamines
  • Neurotransmitters
  • Receptors
  • Striatum

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Wenk, G. L., Pierce, D. J., Struble, R. G., Price, D. L., & Cork, L. C. (1989). Age-related changes in multiple neurotransmitter systems in the monkey brain. Neurobiology of Aging, 10(1), 11-19. https://doi.org/10.1016/S0197-4580(89)80005-3

Age-related changes in multiple neurotransmitter systems in the monkey brain. / Wenk, Gary L.; Pierce, Donna J.; Struble, Robert G.; Price, Donald L.; Cork, Linda C.

In: Neurobiology of Aging, Vol. 10, No. 1, 1989, p. 11-19.

Research output: Contribution to journalArticle

Wenk, GL, Pierce, DJ, Struble, RG, Price, DL & Cork, LC 1989, 'Age-related changes in multiple neurotransmitter systems in the monkey brain', Neurobiology of Aging, vol. 10, no. 1, pp. 11-19. https://doi.org/10.1016/S0197-4580(89)80005-3
Wenk, Gary L. ; Pierce, Donna J. ; Struble, Robert G. ; Price, Donald L. ; Cork, Linda C. / Age-related changes in multiple neurotransmitter systems in the monkey brain. In: Neurobiology of Aging. 1989 ; Vol. 10, No. 1. pp. 11-19.
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