Age-related changes in central nervous system beta-endorphin and ACTH

S. R. Gambert, T. L. Garthwaite, C. H. Pontzer, T. C. Hagen

Research output: Contribution to journalArticle

Abstract

Aging is associated with alterations in mood, thermoregulation, pain threshold, and stress response. Because these functions may be modulated by endogenous opiates, we measured immunoreactive ACTH and β-endorphin in discrete brain areas and pituitary glands from rats aged 6 weeks (young), 6 months (mature), and 20–24 months (senescent). β-Endorphin and ACTH declined significantly with aging in the hypothalamus and corpus striatum. β-Endorphin and ACTH increased in the frontal lobe during early life; however, no change was noted after maturity. A discordant response with age was noted in the pituitary in that ACTH did not change, while β-endorphin increased early in life without change after maturity. Cerebellar tissue exhibited no immunoreactive ACTH or β-endorphin. Age-related changes in brain and pituitary β-endorphin and ACTH must be considered in the evaluation of the physiological aging process and when comparing studies of these neuropeptides.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalNeuroendocrinology
Volume31
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Endorphins
beta-Endorphin
Adrenocorticotropic Hormone
Central Nervous System
Physiological Phenomena
Corpus Striatum
Pain Threshold
Opioid Peptides
Body Temperature Regulation
Brain
Frontal Lobe
Pituitary Gland
Neuropeptides
Hypothalamus

Keywords

  • ACTH
  • Age
  • Brain
  • Pituitary
  • β-Endorphin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Gambert, S. R., Garthwaite, T. L., Pontzer, C. H., & Hagen, T. C. (1980). Age-related changes in central nervous system beta-endorphin and ACTH. Neuroendocrinology, 31(4), 252-255. https://doi.org/10.1159/000123083

Age-related changes in central nervous system beta-endorphin and ACTH. / Gambert, S. R.; Garthwaite, T. L.; Pontzer, C. H.; Hagen, T. C.

In: Neuroendocrinology, Vol. 31, No. 4, 1980, p. 252-255.

Research output: Contribution to journalArticle

Gambert, SR, Garthwaite, TL, Pontzer, CH & Hagen, TC 1980, 'Age-related changes in central nervous system beta-endorphin and ACTH', Neuroendocrinology, vol. 31, no. 4, pp. 252-255. https://doi.org/10.1159/000123083
Gambert, S. R. ; Garthwaite, T. L. ; Pontzer, C. H. ; Hagen, T. C. / Age-related changes in central nervous system beta-endorphin and ACTH. In: Neuroendocrinology. 1980 ; Vol. 31, No. 4. pp. 252-255.
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