Age-related changes in brain hemodynamics; A calibrated MRI study

J. B. De Vis, J. Hendrikse, A. Bhogal, A. Adams, L. J. Kappelle, E. T. Petersen

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Blood oxygenation-level dependent (BOLD) magnetic resonance imaging signal changes in response to stimuli have been used to evaluate age-related changes in neuronal activity. Contradictory results from these types of experiments have been attributed to differences in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2). To clarify the effects of these physiological parameters, we investigated the effect of age on baseline CBF and CMRO2. Materials and Methods: Twenty young (mean±sd age, 28±3 years), and 45 older subjects (66±4 years) were investigated. A dual-echo pseudocontinuous arterial spin labeling (ASL) sequence was performed during normocapnic, hypercapnic, and hyperoxic breathing challenges. Whole brain and regional gray matter values of CBF, ASL cerebrovascular reactivity (CVR), BOLD CVR, oxygen extraction fraction (OEF), and CMRO2 were calculated. Results: Whole brain CBF was 49±14 and 40±9 ml/100 g/min in young and older subjects respectively (P<0.05). Age-related differences in CBF decreased to the point of nonsignificance (B=-4.1, SE=3.8) when EtCO2 was added as a confounder. BOLD CVR was lower in the whole brain, in the frontal, in the temporal, and in the occipital of the older subjects (P<0.05). Whole brain OEF was 43±8% in the young and 39±6% in the older subjects (P=0.066). Whole brain CMRO2 was 181±60 and 133±43 μmol/100 g/min in young and older subjects, respectively (P<0.01). Discussion: Age-related differences in CBF could potentially be explained by differences in EtCO2. Regional CMRO2 was lower in older subjects. BOLD studies should take this into account when investigating age-related changes in neuronal activity.

Original languageEnglish (US)
Pages (from-to)3973-3987
Number of pages15
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Ageing
  • Calibrated magnetic resonance imaging
  • Cerebral blood flow
  • Cerebral metabolic rate of oxygen

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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