Age-related changes in brain glucose metabolism in adults with attention-deficit/hyperactivity disorder and control subjects

Monique Ernst, Alan J. Zametkin, Robert L. Phillips, Robert M. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Using positron emission tomography and [18F]-2-fluoro-2-deoxy-D-glucose, the authors determined cerebral metabolic rates for glucose (CMRglc) in 39 adults (18-51 years old) with attention deficit/hyperactivity disorder (ADHD) and 56 healthy control adults (19-56 years old) during the performance of a continuous attention task. Increased age was associated with reduced global CMRglc in ADHD women, but not in ADHD men, control men, or control women. Better performance on the attention task was significantly associated with increased age only in the ADHD female group. Determining the role of behavioral, hormonal, and genetic factors is a challenge for future research.

Original languageEnglish (US)
Pages (from-to)168-177
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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