TY - JOUR
T1 - Age-related changes in brain glucose metabolism in adults with attention-deficit/hyperactivity disorder and control subjects
AU - Ernst, Monique
AU - Zametkin, Alan J.
AU - Phillips, Robert L.
AU - Cohen, Robert M.
PY - 1998
Y1 - 1998
N2 - Using positron emission tomography and [18F]-2-fluoro-2-deoxy-D-glucose, the authors determined cerebral metabolic rates for glucose (CMRglc) in 39 adults (18-51 years old) with attention deficit/hyperactivity disorder (ADHD) and 56 healthy control adults (19-56 years old) during the performance of a continuous attention task. Increased age was associated with reduced global CMRglc in ADHD women, but not in ADHD men, control men, or control women. Better performance on the attention task was significantly associated with increased age only in the ADHD female group. Determining the role of behavioral, hormonal, and genetic factors is a challenge for future research.
AB - Using positron emission tomography and [18F]-2-fluoro-2-deoxy-D-glucose, the authors determined cerebral metabolic rates for glucose (CMRglc) in 39 adults (18-51 years old) with attention deficit/hyperactivity disorder (ADHD) and 56 healthy control adults (19-56 years old) during the performance of a continuous attention task. Increased age was associated with reduced global CMRglc in ADHD women, but not in ADHD men, control men, or control women. Better performance on the attention task was significantly associated with increased age only in the ADHD female group. Determining the role of behavioral, hormonal, and genetic factors is a challenge for future research.
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U2 - 10.1176/jnp.10.2.168
DO - 10.1176/jnp.10.2.168
M3 - Article
C2 - 9608405
AN - SCOPUS:0031745709
SN - 0895-0172
VL - 10
SP - 168
EP - 177
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 2
ER -