TY - JOUR
T1 - Age-related changes in astrocytic and ependymal cells of the subventricular zone
AU - Capilla-Gonzalez, Vivian
AU - Cebrian-Silla, Arantxa
AU - Guerrero-Cazares, Hugo
AU - Garcia-Verdugo, Jose Manuel
AU - Quiñones-Hinojosa, Alfredo
PY - 2014/5
Y1 - 2014/5
N2 - Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence.
AB - Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence.
KW - Aging
KW - Astrocytes
KW - Ependymal cells
KW - Neural stem cells
KW - Subventricular zone
KW - Ultrastructure
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UR - http://www.scopus.com/inward/citedby.url?scp=84896316261&partnerID=8YFLogxK
U2 - 10.1002/glia.22642
DO - 10.1002/glia.22642
M3 - Article
C2 - 24677590
AN - SCOPUS:84896316261
SN - 0894-1491
VL - 62
SP - 790
EP - 803
JO - Glia
JF - Glia
IS - 5
ER -