Age-related changes in Arc transcription and DNA methylation within the hippocampus

M. R. Penner, T. L. Roth, M. K. Chawla, L. T. Hoang, E. D. Roth, F. D. Lubin, J. D. Sweatt, Paul F Worley, C. A. Barnes

Research output: Contribution to journalArticle

Abstract

The transcription of genes that support memory processes are likely to be impacted by the normal aging process. Because Arc is necessary for memory consolidation and enduring synaptic plasticity, we examined Arc transcription within the aged hippocampus. Here, we report that Arc transcription is reduced within the aged hippocampus compared to the adult hippocampus during both "off line" periods of rest, and following spatial behavior. This reduction is observed within ensembles of CA1 "place cells", which make less mRNA per cell, and in the dentate gyrus (DG) where fewer granule cells are activated by behavior. In addition, we present data suggesting that aberrant changes in methylation of the Arc gene may be responsible for age-related decreases in Arc transcription within CA1 and the DG. Given that Arc is necessary for normal memory function, these subregion-specific epigenetic and transcriptional changes may result in less efficient memory storage and retrieval during aging.

Original languageEnglish (US)
Pages (from-to)2198-2210
Number of pages13
JournalNeurobiology of Aging
Volume32
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

DNA Methylation
Hippocampus
Dentate Gyrus
Spatial Behavior
Neuronal Plasticity
Epigenomics
Methylation
Genes
Messenger RNA

Keywords

  • Epigenetics
  • Hippocampus
  • Immediate-early gene
  • Normal aging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Penner, M. R., Roth, T. L., Chawla, M. K., Hoang, L. T., Roth, E. D., Lubin, F. D., ... Barnes, C. A. (2011). Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiology of Aging, 32(12), 2198-2210. https://doi.org/10.1016/j.neurobiolaging.2010.01.009

Age-related changes in Arc transcription and DNA methylation within the hippocampus. / Penner, M. R.; Roth, T. L.; Chawla, M. K.; Hoang, L. T.; Roth, E. D.; Lubin, F. D.; Sweatt, J. D.; Worley, Paul F; Barnes, C. A.

In: Neurobiology of Aging, Vol. 32, No. 12, 12.2011, p. 2198-2210.

Research output: Contribution to journalArticle

Penner, MR, Roth, TL, Chawla, MK, Hoang, LT, Roth, ED, Lubin, FD, Sweatt, JD, Worley, PF & Barnes, CA 2011, 'Age-related changes in Arc transcription and DNA methylation within the hippocampus', Neurobiology of Aging, vol. 32, no. 12, pp. 2198-2210. https://doi.org/10.1016/j.neurobiolaging.2010.01.009
Penner, M. R. ; Roth, T. L. ; Chawla, M. K. ; Hoang, L. T. ; Roth, E. D. ; Lubin, F. D. ; Sweatt, J. D. ; Worley, Paul F ; Barnes, C. A. / Age-related changes in Arc transcription and DNA methylation within the hippocampus. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 12. pp. 2198-2210.
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