Age of first drunkenness and risks for all-cause mortality: A 27-year follow-up from the epidemiologic catchment area study

Hui Hu, William W. Eaton, James C. Anthony, Li Tzy Wu, Linda B. Cottler

Research output: Research - peer-reviewArticle

Abstract

Background Early-onset drunkenness is associated with an increased risk of developing an alcohol use disorder (AUD), which predicts excess mortality risk. Here, we estimated mortality risk for drinkers with and without early drunkenness. Methods For 14,848 adult participants interviewed about drinking, drunken episodes, and AUD in 1981–83 for the Epidemiologic Catchment Area in New Haven (Connecticut), Baltimore (Maryland), St. Louis (Missouri), and Durham (North Carolina), we linked National Death Index records through 2007. Results Cox regression modeling estimates showed excess mortality for drinkers with age of first drunkenness earlier than 15 years old (hazard ratio, HR: 1.47, 95% CI: 1.25, 1.72) and when first drunkenness occurred at or after age 15 (HR: 1.20, 95% CI: 1.11, 1.29), as compared with adults who had never been drunk. Consistent results were observed, irrespective of AUD history. That is, early drunkenness signaled excess mortality risk even in absence of AUD. Conclusions In a large community sample from four cities in the US, early age of onset of drunkenness predicts mortality risk. We discuss experiments to investigate the possible causal significance of this predictive association.

LanguageEnglish (US)
Pages148-153
Number of pages6
JournalDrug and Alcohol Dependence
Volume176
DOIs
StatePublished - Jul 1 2017

Fingerprint

Alcoholic Intoxication
Mortality
Catchments
Alcohols
Hazards
Experiments
Baltimore
Death Certificates
Age of Onset
Drinking
History

Keywords

  • Alcohol use disorder
  • Drunkenness
  • Epidemiologic catchment area program
  • Mortality

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Age of first drunkenness and risks for all-cause mortality : A 27-year follow-up from the epidemiologic catchment area study. / Hu, Hui; Eaton, William W.; Anthony, James C.; Wu, Li Tzy; Cottler, Linda B.

In: Drug and Alcohol Dependence, Vol. 176, 01.07.2017, p. 148-153.

Research output: Research - peer-reviewArticle

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