Age of diagnosis influences serologic responses in children with Crohn's disease: A possible clue to etiology?

James Markowirz, Subra Kugathasan, Marla Dubinsky, Ling Mei, Wallace Crandall, Neal LeLeiko, Maria Oliva-Hemker, Joel Rosh, Jonathan Evans, David Mack, Anthony Otley, Marian Pfefferkorn, Ron Bahar, Eric Vasiliauskas, Ghassan Wahbeh, Gary Silber, J. Antonio Quiros, Iwona Wrobel, Justin Nebel, Carol LandersYoanna Picornell, Stephan Targan, Trudy Lerer, Jeffrey Hyams

Research output: Contribution to journalArticle

Abstract

Background: Crohn's disease (CD) is often associated with antibodies to microbial antigens. Differences in immune response may offer clues to the pathogenesis of the disease. The aim was to examine the influence of age at diagnosis on the serologic response in children with CD. Methods: Data were drawn from 3 North American multicenter pediatric inflammatory bowel disease (IBD) research consortia. At or shortly after diagnosis, pANCA, ASCA IgA, ASCA IgG, anti-ompC, and anti-CBir1 were assayed. The results were compared as a function of age at CD diagnosis (0-7 years versus 8-15 years). Results: In all, 705 children (79

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalInflammatory Bowel Diseases
Volume15
Issue number5
DOIs
StatePublished - 2009

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Crohn Disease
Inflammatory Bowel Diseases
Immunoglobulin A
Pediatrics
Antigens
Antibodies
Research
anti-IgG

Keywords

  • Children
  • Crohn's disease
  • Serologic responses

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Markowirz, J., Kugathasan, S., Dubinsky, M., Mei, L., Crandall, W., LeLeiko, N., ... Hyams, J. (2009). Age of diagnosis influences serologic responses in children with Crohn's disease: A possible clue to etiology? Inflammatory Bowel Diseases, 15(5), 714-719. https://doi.org/10.1002/ibd.20831

Age of diagnosis influences serologic responses in children with Crohn's disease : A possible clue to etiology? / Markowirz, James; Kugathasan, Subra; Dubinsky, Marla; Mei, Ling; Crandall, Wallace; LeLeiko, Neal; Oliva-Hemker, Maria; Rosh, Joel; Evans, Jonathan; Mack, David; Otley, Anthony; Pfefferkorn, Marian; Bahar, Ron; Vasiliauskas, Eric; Wahbeh, Ghassan; Silber, Gary; Quiros, J. Antonio; Wrobel, Iwona; Nebel, Justin; Landers, Carol; Picornell, Yoanna; Targan, Stephan; Lerer, Trudy; Hyams, Jeffrey.

In: Inflammatory Bowel Diseases, Vol. 15, No. 5, 2009, p. 714-719.

Research output: Contribution to journalArticle

Markowirz, J, Kugathasan, S, Dubinsky, M, Mei, L, Crandall, W, LeLeiko, N, Oliva-Hemker, M, Rosh, J, Evans, J, Mack, D, Otley, A, Pfefferkorn, M, Bahar, R, Vasiliauskas, E, Wahbeh, G, Silber, G, Quiros, JA, Wrobel, I, Nebel, J, Landers, C, Picornell, Y, Targan, S, Lerer, T & Hyams, J 2009, 'Age of diagnosis influences serologic responses in children with Crohn's disease: A possible clue to etiology?', Inflammatory Bowel Diseases, vol. 15, no. 5, pp. 714-719. https://doi.org/10.1002/ibd.20831
Markowirz, James ; Kugathasan, Subra ; Dubinsky, Marla ; Mei, Ling ; Crandall, Wallace ; LeLeiko, Neal ; Oliva-Hemker, Maria ; Rosh, Joel ; Evans, Jonathan ; Mack, David ; Otley, Anthony ; Pfefferkorn, Marian ; Bahar, Ron ; Vasiliauskas, Eric ; Wahbeh, Ghassan ; Silber, Gary ; Quiros, J. Antonio ; Wrobel, Iwona ; Nebel, Justin ; Landers, Carol ; Picornell, Yoanna ; Targan, Stephan ; Lerer, Trudy ; Hyams, Jeffrey. / Age of diagnosis influences serologic responses in children with Crohn's disease : A possible clue to etiology?. In: Inflammatory Bowel Diseases. 2009 ; Vol. 15, No. 5. pp. 714-719.
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