Age is positively associated with high-density lipoprotein cholesterol among African Americans in cross-sectional analysis: The Jackson Heart Study

Jane L. Harman, Michael E. Griswold, Neal O. Jeffries, Anne E. Sumner, Daniel F. Sarpong, Ermeg L. Akylbekova, Evelyn R. Walker, Sharon B. Wyatt, Herman A. Taylor

Research output: Contribution to journalArticle

Abstract

Background: African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities. Objective: We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans. Methods: Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men). Results: HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men. Conclusions: Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalJournal of Clinical Lipidology
Volume5
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • African Americans
  • Aging
  • Cohort studies
  • Epidemiology
  • High-density lipoprotein cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

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    Harman, J. L., Griswold, M. E., Jeffries, N. O., Sumner, A. E., Sarpong, D. F., Akylbekova, E. L., Walker, E. R., Wyatt, S. B., & Taylor, H. A. (2011). Age is positively associated with high-density lipoprotein cholesterol among African Americans in cross-sectional analysis: The Jackson Heart Study. Journal of Clinical Lipidology, 5(3), 173-178. https://doi.org/10.1016/j.jacl.2011.02.002