TY - JOUR
T1 - Age is positively associated with high-density lipoprotein cholesterol among African Americans in cross-sectional analysis
T2 - The Jackson Heart Study
AU - Harman, Jane L.
AU - Griswold, Michael E.
AU - Jeffries, Neal O.
AU - Sumner, Anne E.
AU - Sarpong, Daniel F.
AU - Akylbekova, Ermeg L.
AU - Walker, Evelyn R.
AU - Wyatt, Sharon B.
AU - Taylor, Herman A.
N1 - Funding Information:
The Jackson Heart Study is conducted by the Jackson State University, the University of Mississippi Medical Center, and Tougaloo College and is supported by National Institutes of Health contracts N01-HC-95170, N01-HC-95171, and N01-HC-95172 from the National Heart, Lung and Blood Institute and the National Institute for Minority Health and Health Disparities. Anne E. Sumner is supported by the intramural program of the National Institute of Diabetes and Digestive and Kidney Diseases.
PY - 2011/5
Y1 - 2011/5
N2 - Background: African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities. Objective: We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans. Methods: Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men). Results: HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men. Conclusions: Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect.
AB - Background: African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities. Objective: We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans. Methods: Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men). Results: HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men. Conclusions: Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect.
KW - African Americans
KW - Aging
KW - Cohort studies
KW - Epidemiology
KW - High-density lipoprotein cholesterol
KW - Triglycerides
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U2 - 10.1016/j.jacl.2011.02.002
DO - 10.1016/j.jacl.2011.02.002
M3 - Article
C2 - 21600522
AN - SCOPUS:79956267695
SN - 1933-2874
VL - 5
SP - 173
EP - 178
JO - Journal of clinical lipidology
JF - Journal of clinical lipidology
IS - 3
ER -