Age Impacts Ability of Aspartate–Alanine Aminotransferase Ratio to Predict Advanced Fibrosis in Nonalcoholic Fatty Liver Disease

George Boon Bee Goh, Mangesh R. Pagadala, Jaividhya Dasarathy, Aynur Unalp-Arida, Rish K. Pai, Lisa Yerian, Amer Khiyami, Achuthan Sourianarayanane, Ruth Sargent, Carol Hawkins, Srinivasan Dasarathy, Arthur J. McCullough

Research output: Contribution to journalArticle

Abstract

Background and Aim: While histological differences have been reported between pediatric and adult nonalcoholic fatty liver disease (NAFLD), potential age-related changes in serum transaminases and liver histology remain largely unexplored. Our study sought to investigate the clinical and histological characteristics of NAFLD across age. Methods: This was a prospective cross-sectional study of 502 biopsy-proven NAFLD patients. Clinical data were evaluated and compared among different age groups; group A (ages 18–44), B (ages 45–64), and C (≥ages 65). Results: 34.9, 56.0, and 9.1 % of the cohort were distributed among group A, B, and C, respectively. While the prevalence of nonalcoholic steatohepatitis (NASH) was comparable across age groups, the prevalence of advanced fibrosis increased with age (p = 0.000). Although the mean ALT progressively decreased with age; 87, 64, 56 U/L in group A, B, and C, respectively (p = 0.000), there was no difference in mean AST (p = 0.939) across age. The AST:ALT ratio (AAR) progressively increased from 0.7, 0.9, and 1.1 in group A, B, and C, respectively (p = 0.000). In group C, an AAR ≥1 was found in 74 and 40 % of patients with and without advanced fibrosis. Conclusion: With advancing age, ALT levels progressively declined while AST levels remained stable, leading to a higher AAR. Although higher AAR is often used as a surrogate measure of advanced fibrosis, advancing age can also contribute to increased AAR. In fact, an AAR ≥1 was found in significant number of elderly patients without advanced fibrosis. Consequently, an increased AAR may be a function of decreasing ALT with age in addition to progressive fibrosis.

Original languageEnglish (US)
Pages (from-to)1825-1831
Number of pages7
JournalDigestive Diseases and Sciences
Volume60
Issue number6
DOIs
StatePublished - Feb 24 2015
Externally publishedYes

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Transaminases
Fibrosis
Age Groups
Histology
Cross-Sectional Studies
Non-alcoholic Fatty Liver Disease
Pediatrics
Biopsy
Liver
Serum

Keywords

  • Advanced fibrosis
  • Age-related changes
  • Liver transaminases
  • NAFLD

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Medicine(all)

Cite this

Goh, G. B. B., Pagadala, M. R., Dasarathy, J., Unalp-Arida, A., Pai, R. K., Yerian, L., ... McCullough, A. J. (2015). Age Impacts Ability of Aspartate–Alanine Aminotransferase Ratio to Predict Advanced Fibrosis in Nonalcoholic Fatty Liver Disease. Digestive Diseases and Sciences, 60(6), 1825-1831. https://doi.org/10.1007/s10620-015-3529-8

Age Impacts Ability of Aspartate–Alanine Aminotransferase Ratio to Predict Advanced Fibrosis in Nonalcoholic Fatty Liver Disease. / Goh, George Boon Bee; Pagadala, Mangesh R.; Dasarathy, Jaividhya; Unalp-Arida, Aynur; Pai, Rish K.; Yerian, Lisa; Khiyami, Amer; Sourianarayanane, Achuthan; Sargent, Ruth; Hawkins, Carol; Dasarathy, Srinivasan; McCullough, Arthur J.

In: Digestive Diseases and Sciences, Vol. 60, No. 6, 24.02.2015, p. 1825-1831.

Research output: Contribution to journalArticle

Goh, GBB, Pagadala, MR, Dasarathy, J, Unalp-Arida, A, Pai, RK, Yerian, L, Khiyami, A, Sourianarayanane, A, Sargent, R, Hawkins, C, Dasarathy, S & McCullough, AJ 2015, 'Age Impacts Ability of Aspartate–Alanine Aminotransferase Ratio to Predict Advanced Fibrosis in Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 60, no. 6, pp. 1825-1831. https://doi.org/10.1007/s10620-015-3529-8
Goh, George Boon Bee ; Pagadala, Mangesh R. ; Dasarathy, Jaividhya ; Unalp-Arida, Aynur ; Pai, Rish K. ; Yerian, Lisa ; Khiyami, Amer ; Sourianarayanane, Achuthan ; Sargent, Ruth ; Hawkins, Carol ; Dasarathy, Srinivasan ; McCullough, Arthur J. / Age Impacts Ability of Aspartate–Alanine Aminotransferase Ratio to Predict Advanced Fibrosis in Nonalcoholic Fatty Liver Disease. In: Digestive Diseases and Sciences. 2015 ; Vol. 60, No. 6. pp. 1825-1831.
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abstract = "Background and Aim: While histological differences have been reported between pediatric and adult nonalcoholic fatty liver disease (NAFLD), potential age-related changes in serum transaminases and liver histology remain largely unexplored. Our study sought to investigate the clinical and histological characteristics of NAFLD across age. Methods: This was a prospective cross-sectional study of 502 biopsy-proven NAFLD patients. Clinical data were evaluated and compared among different age groups; group A (ages 18–44), B (ages 45–64), and C (≥ages 65). Results: 34.9, 56.0, and 9.1 {\%} of the cohort were distributed among group A, B, and C, respectively. While the prevalence of nonalcoholic steatohepatitis (NASH) was comparable across age groups, the prevalence of advanced fibrosis increased with age (p = 0.000). Although the mean ALT progressively decreased with age; 87, 64, 56 U/L in group A, B, and C, respectively (p = 0.000), there was no difference in mean AST (p = 0.939) across age. The AST:ALT ratio (AAR) progressively increased from 0.7, 0.9, and 1.1 in group A, B, and C, respectively (p = 0.000). In group C, an AAR ≥1 was found in 74 and 40 {\%} of patients with and without advanced fibrosis. Conclusion: With advancing age, ALT levels progressively declined while AST levels remained stable, leading to a higher AAR. Although higher AAR is often used as a surrogate measure of advanced fibrosis, advancing age can also contribute to increased AAR. In fact, an AAR ≥1 was found in significant number of elderly patients without advanced fibrosis. Consequently, an increased AAR may be a function of decreasing ALT with age in addition to progressive fibrosis.",
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AU - Pagadala, Mangesh R.

AU - Dasarathy, Jaividhya

AU - Unalp-Arida, Aynur

AU - Pai, Rish K.

AU - Yerian, Lisa

AU - Khiyami, Amer

AU - Sourianarayanane, Achuthan

AU - Sargent, Ruth

AU - Hawkins, Carol

AU - Dasarathy, Srinivasan

AU - McCullough, Arthur J.

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N2 - Background and Aim: While histological differences have been reported between pediatric and adult nonalcoholic fatty liver disease (NAFLD), potential age-related changes in serum transaminases and liver histology remain largely unexplored. Our study sought to investigate the clinical and histological characteristics of NAFLD across age. Methods: This was a prospective cross-sectional study of 502 biopsy-proven NAFLD patients. Clinical data were evaluated and compared among different age groups; group A (ages 18–44), B (ages 45–64), and C (≥ages 65). Results: 34.9, 56.0, and 9.1 % of the cohort were distributed among group A, B, and C, respectively. While the prevalence of nonalcoholic steatohepatitis (NASH) was comparable across age groups, the prevalence of advanced fibrosis increased with age (p = 0.000). Although the mean ALT progressively decreased with age; 87, 64, 56 U/L in group A, B, and C, respectively (p = 0.000), there was no difference in mean AST (p = 0.939) across age. The AST:ALT ratio (AAR) progressively increased from 0.7, 0.9, and 1.1 in group A, B, and C, respectively (p = 0.000). In group C, an AAR ≥1 was found in 74 and 40 % of patients with and without advanced fibrosis. Conclusion: With advancing age, ALT levels progressively declined while AST levels remained stable, leading to a higher AAR. Although higher AAR is often used as a surrogate measure of advanced fibrosis, advancing age can also contribute to increased AAR. In fact, an AAR ≥1 was found in significant number of elderly patients without advanced fibrosis. Consequently, an increased AAR may be a function of decreasing ALT with age in addition to progressive fibrosis.

AB - Background and Aim: While histological differences have been reported between pediatric and adult nonalcoholic fatty liver disease (NAFLD), potential age-related changes in serum transaminases and liver histology remain largely unexplored. Our study sought to investigate the clinical and histological characteristics of NAFLD across age. Methods: This was a prospective cross-sectional study of 502 biopsy-proven NAFLD patients. Clinical data were evaluated and compared among different age groups; group A (ages 18–44), B (ages 45–64), and C (≥ages 65). Results: 34.9, 56.0, and 9.1 % of the cohort were distributed among group A, B, and C, respectively. While the prevalence of nonalcoholic steatohepatitis (NASH) was comparable across age groups, the prevalence of advanced fibrosis increased with age (p = 0.000). Although the mean ALT progressively decreased with age; 87, 64, 56 U/L in group A, B, and C, respectively (p = 0.000), there was no difference in mean AST (p = 0.939) across age. The AST:ALT ratio (AAR) progressively increased from 0.7, 0.9, and 1.1 in group A, B, and C, respectively (p = 0.000). In group C, an AAR ≥1 was found in 74 and 40 % of patients with and without advanced fibrosis. Conclusion: With advancing age, ALT levels progressively declined while AST levels remained stable, leading to a higher AAR. Although higher AAR is often used as a surrogate measure of advanced fibrosis, advancing age can also contribute to increased AAR. In fact, an AAR ≥1 was found in significant number of elderly patients without advanced fibrosis. Consequently, an increased AAR may be a function of decreasing ALT with age in addition to progressive fibrosis.

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