Age Effects on Alpha‐1‐Acid Glycoprotein Concentration and Imipramine Plasma Protein Binding

Darrell R. Abernethy

Research output: Contribution to journalArticlepeer-review


Alpha‐1‐acid glycoprotein concentration and imipramine binding to plasma proteins were determined in a cohort of 69 subjects, aged 20–97 years. No subject had evidence of acute or chronic inflammatory disease or malignancy, or was receiving tricyclic antidepressant therapy. Alpha‐1‐acid glycoprotein concentration increased significantly with increasing age (r = 0.28; P < 0.02). Imipramine percentage not bound to plasma proteins was negatively related to alpha‐1‐acid glycoprotein concentration (r = −0.30; P < 0.01); however, there was no relationship between subject age and percentage imipramine unbound. Though alpha‐1‐acid glycoprotein concentration increases with advancing age, because only a small proportion of the variability is explained by age, with other undefined factors being more important, drugs predominantly bound to alpha‐1‐acid glycoprotein such as imipramine may not have a clinically or statistically significant change in protein binding with increasing age in the absence of overt clinical illness. 1984 The American Geriatrics Society

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalJournal of the American Geriatrics Society
Issue number10
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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