Age dependent testicular changes in lead exposed rats

D. K. Saxena, B. Lal, S. V. Chandra

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Daily intraperitoneal injection of lead (8 mg/kg, as Pb-acetate) over a period of 20 days in 1, 3, 5, 7, 9, and 11 weeks old rats revealed marked histopathological changes in the animals exposed from 7-11 weeks of age. These changes were in the form of disrupted spermatogenesis and reduced and atrophic Leydig cells. These histopathological observations appear to be related with the disturbed steroidogenesis which is ultimately responsible for the disrupted spermatogenesis in growing rats.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalJournal of Environmental Biology
Issue number3
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Engineering
  • Toxicology
  • Health, Toxicology and Mutagenesis


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