Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice

Alfredo Kirkwood, Alcino Silva, Mark F. Bear

Research output: Contribution to journalArticlepeer-review

Abstract

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.

Original languageEnglish (US)
Pages (from-to)3380-3383
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number7
DOIs
StatePublished - Apr 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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