Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice

Alfredo Kirkwood; Alcino Silva; Mark F. Bear

doi:10.1073/pnas.94.7.3380

Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice

Alfredo Kirkwood, Alcino Silva, Mark F. Bear

Research output: Contribution to journal › Article › peer-review

Abstract

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.

Original language	English (US)
Pages (from-to)	3380-3383
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	94
Issue number	7
DOIs	https://doi.org/10.1073/pnas.94.7.3380
State	Published - Apr 1 1997
Externally published	Yes

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AB - Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.

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