Abstract
Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
Original language | English (US) |
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Pages (from-to) | 3380-3383 |
Number of pages | 4 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 94 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General