TY - JOUR
T1 - Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice
AU - Kirkwood, Alfredo
AU - Silva, Alcino
AU - Bear, Mark F.
PY - 1997/4/1
Y1 - 1997/4/1
N2 - Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
AB - Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α- calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
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U2 - 10.1073/pnas.94.7.3380
DO - 10.1073/pnas.94.7.3380
M3 - Article
C2 - 9096402
AN - SCOPUS:0030953063
VL - 94
SP - 3380
EP - 3383
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 7
ER -