Age dependence of ultrasonically induced lung hemorrhage in mice

Diane Dalecki, Sally Z. Child, Carol H. Raeman, Christopher Cox, David P. Penney, Edwin L. Carstensen

Research output: Contribution to journalArticlepeer-review

Abstract

Thresholds for ultrasonically induced lung hemorrhage were determined in neonatal mice (2436 h old), juvenile mice (14 d old) and adult mice (8- 10 weeks old) to assess whether or not the threshold for lung hemorrhage is dependent upon age. Ultrasonic exposures were at 1.15 MHz with a pulse length of 10 μs, pulse repetition frequency of 100 Hz and a total exposure duration of 3 min. The threshold for lung hemorrhage occurred at a peak positive acoustic pressure of approximately 1 MPa for mice in all three age groups. Although the thresholds were similar for neonatal, juvenile and adult mice, the sizes of the suprathreshold hemorrhages were significantly larger in adult mice than in neonatal or juvenile mice.

Original languageEnglish (US)
Pages (from-to)767-776
Number of pages10
JournalUltrasound in Medicine and Biology
Volume23
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Bioeffect
  • Hemorrhage
  • Juvenile mouse
  • Lung
  • Neonatal mouse
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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