Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline

Diane Jacobs, M. Sano, K. Marder, K. Bell, F. Bylsma, G. Lafleche, Marilyn Albert, Jason Brandt, Y. Stern

Research output: Contribution to journalArticle

Abstract

We examined the pattern of cognitive impairment and rate of cognitive and functional decline as a function of age at symptom onset in 127 patients with probable Alzheimer's disease (AD). At baseline, early-onset (before age 65) and late-onset groups were mildly and comparably impaired on the modified Mini-Mental State Examination (mMMS) andthe Blessed Dementia Rating Scale-Part 1 (BDRS). Repeated-measures analysis of variance revealed significantly more rapid decline in early-onset subjects overa 2-year follow-up period. Multivariate linear regression analyses indicated that age at symptom onset strongly predicted rate of decline on the mMMS and the BDRS, even after controlling for symptom duration, gender, family history of dementia, and baseline mMMS and BDRS scores. Early-and late-onset AD subjects also differed in terms of pattern of performance on the mMMS. Early-onset subjects scored significantly lower than late-onset subjects on attentionalitems of the mMMS at baseline and follow-up. Conversely, late-onset subjects scored significantly lower than early-onset subjects on memory and naming items at baseline, and thetwogroups were comparable on these tasks at follow-up. Results provide longitudinal evidenceof more rapid cognitive and functional decline in subjects with early-onset AD and suggest that early-onset AD may be characterized by predominant impairment of attentional skills.

LanguageEnglish (US)
Pages1215-1220
Number of pages6
JournalNeurology
Volume44
Issue number7
StatePublished - 1994

Fingerprint

Age of Onset
Alzheimer Disease
Dementia
Linear Models
Analysis of Variance
Regression Analysis
Cognitive Dysfunction
Onset
Alzheimer's Disease
Mental State

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Jacobs, D., Sano, M., Marder, K., Bell, K., Bylsma, F., Lafleche, G., ... Stern, Y. (1994). Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline. Neurology, 44(7), 1215-1220.

Age at onset of Alzheimer's disease : Relation to pattern of cognitive dysfunction and rate of decline. / Jacobs, Diane; Sano, M.; Marder, K.; Bell, K.; Bylsma, F.; Lafleche, G.; Albert, Marilyn; Brandt, Jason; Stern, Y.

In: Neurology, Vol. 44, No. 7, 1994, p. 1215-1220.

Research output: Contribution to journalArticle

Jacobs, D, Sano, M, Marder, K, Bell, K, Bylsma, F, Lafleche, G, Albert, M, Brandt, J & Stern, Y 1994, 'Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline', Neurology, vol. 44, no. 7, pp. 1215-1220.
Jacobs D, Sano M, Marder K, Bell K, Bylsma F, Lafleche G et al. Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline. Neurology. 1994;44(7):1215-1220.
Jacobs, Diane ; Sano, M. ; Marder, K. ; Bell, K. ; Bylsma, F. ; Lafleche, G. ; Albert, Marilyn ; Brandt, Jason ; Stern, Y. / Age at onset of Alzheimer's disease : Relation to pattern of cognitive dysfunction and rate of decline. In: Neurology. 1994 ; Vol. 44, No. 7. pp. 1215-1220.
@article{078b7c86da014c798fe31d6063b1cbe9,
title = "Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline",
abstract = "We examined the pattern of cognitive impairment and rate of cognitive and functional decline as a function of age at symptom onset in 127 patients with probable Alzheimer's disease (AD). At baseline, early-onset (before age 65) and late-onset groups were mildly and comparably impaired on the modified Mini-Mental State Examination (mMMS) andthe Blessed Dementia Rating Scale-Part 1 (BDRS). Repeated-measures analysis of variance revealed significantly more rapid decline in early-onset subjects overa 2-year follow-up period. Multivariate linear regression analyses indicated that age at symptom onset strongly predicted rate of decline on the mMMS and the BDRS, even after controlling for symptom duration, gender, family history of dementia, and baseline mMMS and BDRS scores. Early-and late-onset AD subjects also differed in terms of pattern of performance on the mMMS. Early-onset subjects scored significantly lower than late-onset subjects on attentionalitems of the mMMS at baseline and follow-up. Conversely, late-onset subjects scored significantly lower than early-onset subjects on memory and naming items at baseline, and thetwogroups were comparable on these tasks at follow-up. Results provide longitudinal evidenceof more rapid cognitive and functional decline in subjects with early-onset AD and suggest that early-onset AD may be characterized by predominant impairment of attentional skills.",
author = "Diane Jacobs and M. Sano and K. Marder and K. Bell and F. Bylsma and G. Lafleche and Marilyn Albert and Jason Brandt and Y. Stern",
year = "1994",
language = "English (US)",
volume = "44",
pages = "1215--1220",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Age at onset of Alzheimer's disease

T2 - Neurology

AU - Jacobs, Diane

AU - Sano, M.

AU - Marder, K.

AU - Bell, K.

AU - Bylsma, F.

AU - Lafleche, G.

AU - Albert, Marilyn

AU - Brandt, Jason

AU - Stern, Y.

PY - 1994

Y1 - 1994

N2 - We examined the pattern of cognitive impairment and rate of cognitive and functional decline as a function of age at symptom onset in 127 patients with probable Alzheimer's disease (AD). At baseline, early-onset (before age 65) and late-onset groups were mildly and comparably impaired on the modified Mini-Mental State Examination (mMMS) andthe Blessed Dementia Rating Scale-Part 1 (BDRS). Repeated-measures analysis of variance revealed significantly more rapid decline in early-onset subjects overa 2-year follow-up period. Multivariate linear regression analyses indicated that age at symptom onset strongly predicted rate of decline on the mMMS and the BDRS, even after controlling for symptom duration, gender, family history of dementia, and baseline mMMS and BDRS scores. Early-and late-onset AD subjects also differed in terms of pattern of performance on the mMMS. Early-onset subjects scored significantly lower than late-onset subjects on attentionalitems of the mMMS at baseline and follow-up. Conversely, late-onset subjects scored significantly lower than early-onset subjects on memory and naming items at baseline, and thetwogroups were comparable on these tasks at follow-up. Results provide longitudinal evidenceof more rapid cognitive and functional decline in subjects with early-onset AD and suggest that early-onset AD may be characterized by predominant impairment of attentional skills.

AB - We examined the pattern of cognitive impairment and rate of cognitive and functional decline as a function of age at symptom onset in 127 patients with probable Alzheimer's disease (AD). At baseline, early-onset (before age 65) and late-onset groups were mildly and comparably impaired on the modified Mini-Mental State Examination (mMMS) andthe Blessed Dementia Rating Scale-Part 1 (BDRS). Repeated-measures analysis of variance revealed significantly more rapid decline in early-onset subjects overa 2-year follow-up period. Multivariate linear regression analyses indicated that age at symptom onset strongly predicted rate of decline on the mMMS and the BDRS, even after controlling for symptom duration, gender, family history of dementia, and baseline mMMS and BDRS scores. Early-and late-onset AD subjects also differed in terms of pattern of performance on the mMMS. Early-onset subjects scored significantly lower than late-onset subjects on attentionalitems of the mMMS at baseline and follow-up. Conversely, late-onset subjects scored significantly lower than early-onset subjects on memory and naming items at baseline, and thetwogroups were comparable on these tasks at follow-up. Results provide longitudinal evidenceof more rapid cognitive and functional decline in subjects with early-onset AD and suggest that early-onset AD may be characterized by predominant impairment of attentional skills.

UR - http://www.scopus.com/inward/record.url?scp=0027930338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027930338&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 1215

EP - 1220

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -