TY - JOUR
T1 - Age at onset in bipolar I affective disorder
T2 - Further evidence for three subgroups
AU - Bellivier, Frank
AU - Golmard, Jean Louis
AU - Rietschel, Marcella
AU - Schulze, Thomas G.
AU - Malafosse, Alain
AU - Preisig, Martin
AU - McKeon, Patrick
AU - Mynett-Johnson, Lesley
AU - Henry, Chantal
AU - Leboyer, Marion
PY - 2003/5
Y1 - 2003/5
N2 - Objective: Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup. Method: Admixture analysis was used to determine the best-fitting model for the observed ages at onset of 368 consecutively admitted patients. The results obtained were compared with those of the previously described model. The authors also investigated whether affected siblings are more likely to belong to the same theoretical age-at-onset subgroup as identified by admixture analysis. Results: The existence of three subgroups defined by age at onset was confirmed. The mean ages estimated in this model were 17.4 years (SD=2.3), 25.1 years (SD=6.2), and 40.4 years (SD=11.3). Affected siblings were more likely to belong to the same theoretical subgroup. Conclusions: There are three age-at-onset subgroups of bipolar patients, and specific familial vulnerability factors might underlie each subgroup.
AB - Objective: Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup. Method: Admixture analysis was used to determine the best-fitting model for the observed ages at onset of 368 consecutively admitted patients. The results obtained were compared with those of the previously described model. The authors also investigated whether affected siblings are more likely to belong to the same theoretical age-at-onset subgroup as identified by admixture analysis. Results: The existence of three subgroups defined by age at onset was confirmed. The mean ages estimated in this model were 17.4 years (SD=2.3), 25.1 years (SD=6.2), and 40.4 years (SD=11.3). Affected siblings were more likely to belong to the same theoretical subgroup. Conclusions: There are three age-at-onset subgroups of bipolar patients, and specific familial vulnerability factors might underlie each subgroup.
UR - http://www.scopus.com/inward/record.url?scp=0038182399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038182399&partnerID=8YFLogxK
U2 - 10.1176/appi.ajp.160.5.999
DO - 10.1176/appi.ajp.160.5.999
M3 - Article
C2 - 12727708
AN - SCOPUS:0038182399
SN - 0002-953X
VL - 160
SP - 999
EP - 1001
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 5
ER -