Age at menarche, androgen concentrations, and midlife obesity: findings from the Midlife Womenʼs Health Study

Lisa Gallicchio, Jodi A. Flaws, Rebecca L. Smith

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Studies have shown that earlier age at menarche is associated with a higher risk of midlife obesity; however, the mechanism underlying this association is not known. The purpose of this study was to examine whether the association between age at menarche and midlife obesity is due to variation in circulating androgen concentrations. METHODS:: Baseline data were analyzed from 748 women aged 45 to 54 years enrolled in the Midlife Womenʼs Health Study, a prospective cohort study conducted in the Baltimore, MD region. Information on age at menarche was collected through a self-administered questionnaire. Body mass index (BMI) was calculated using height and weight measured at a clinic visit. Obesity was defined as a BMI between 30 and 34.9 kg/m; super obesity was defined as a BMI greater than 35 kg/m. Testosterone, estradiol, and sex hormone-binding globulin were measured in blood samples using enzyme-linked immunosorbent assays. The free androgen index (FAI) was calculated using the formula: (testosterone × 3.467)/sex hormone-binding globulin × 100. RESULTS:: After adjustment for covariates, for each year increase in age at menarche, the odds of obesity and super obesity decreased by 31% (odds ratio (OR) 0.69; 95% confidence limits (CL) 0.59, 0.81) and 34% (OR 0.66; 95% CL 0.52, 0.83), respectively. Addition of the FAI into the models did not attenuate the observed estimates. CONCLUSIONS:: The results of this study indicate that age at menarche is associated with midlife obesity independent of free testosterone concentrations measured in adulthood.

Original languageEnglish (US)
JournalMenopause
DOIs
StateAccepted/In press - Jul 18 2016
Externally publishedYes

Fingerprint

Menarche
Women's Health
Androgens
Obesity
Testosterone
Sex Hormone-Binding Globulin
Body Mass Index
Odds Ratio
Baltimore
Ambulatory Care
Estradiol
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Prospective Studies
Weights and Measures

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Age at menarche, androgen concentrations, and midlife obesity : findings from the Midlife Womenʼs Health Study. / Gallicchio, Lisa; Flaws, Jodi A.; Smith, Rebecca L.

In: Menopause, 18.07.2016.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE:: Studies have shown that earlier age at menarche is associated with a higher risk of midlife obesity; however, the mechanism underlying this association is not known. The purpose of this study was to examine whether the association between age at menarche and midlife obesity is due to variation in circulating androgen concentrations. METHODS:: Baseline data were analyzed from 748 women aged 45 to 54 years enrolled in the Midlife Womenʼs Health Study, a prospective cohort study conducted in the Baltimore, MD region. Information on age at menarche was collected through a self-administered questionnaire. Body mass index (BMI) was calculated using height and weight measured at a clinic visit. Obesity was defined as a BMI between 30 and 34.9 kg/m; super obesity was defined as a BMI greater than 35 kg/m. Testosterone, estradiol, and sex hormone-binding globulin were measured in blood samples using enzyme-linked immunosorbent assays. The free androgen index (FAI) was calculated using the formula: (testosterone × 3.467)/sex hormone-binding globulin × 100. RESULTS:: After adjustment for covariates, for each year increase in age at menarche, the odds of obesity and super obesity decreased by 31{\%} (odds ratio (OR) 0.69; 95{\%} confidence limits (CL) 0.59, 0.81) and 34{\%} (OR 0.66; 95{\%} CL 0.52, 0.83), respectively. Addition of the FAI into the models did not attenuate the observed estimates. CONCLUSIONS:: The results of this study indicate that age at menarche is associated with midlife obesity independent of free testosterone concentrations measured in adulthood.",
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